The functions of mechanosensitive ion channels in tooth and bone tissues.
The functions of mechanosensitive ion channels in tooth and bone tissues.
复制标题
DOI：
10.1016/j.cellsig.2020.109877
复制
发表时间：
2020-12
影响因子：
4.8
通讯作者：
Fang Pei;Jialing Liu;Lan Zhang;X. Pan;Wei Huang;X. Cen;Shishu Huang;Ying Jin;Zhihe Zhao
中科院分区：
文献类型：
--
作者：
Fang Pei;Jialing Liu;Lan Zhang;X. Pan;Wei Huang;X. Cen;Shishu Huang;Ying Jin;Zhihe Zhao
牙齿和骨骼是关系密切的独立组织。两者都是由高度钙化的外部结构和柔软的内部组织组成，两者都在不断地承受机械应力。特别是牙槽骨和牙齿构成一个咬合系统，承受咀嚼力和咬合力。因此，机械转导是牙齿和骨骼许多发育、生理和病理过程的关键过程。机械敏感离子通道如Piezo1和Piezo2是机械转导的重要参与者，但它们在牙齿和骨骼中的功能尚不清楚。本文综述了目前我们对机械敏感离子通道及其在牙齿和骨组织中的作用的认识。这些领域的研究可能会为牙齿和骨组织的调节以及影响这些组织的疾病的潜在治疗提供新的线索。
Tooth and bone are independent tissues with a close relationship. Both are composed of a highly calcified outer structure and soft inner tissue, and both are constantly under mechanical stress. In particular, the alveolar bone and tooth constitute an occlusion system and suffer from masticatory and occlusal force. Thus, mechanotransduction is a key process in many developmental, physiological and pathological processes in tooth and bone. Mechanosensitive ion channels such as Piezo1 and Piezo2 are important participants in mechanotransduction, but their functions in tooth and bone are poorly understood. This review summarizes our current understanding of mechanosensitive ion channels and their roles in tooth and bone tissues. Research in these areas may shed new light on the regulation of tooth and bone tissues and potential treatments for diseases affecting these tissues.