NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis.
NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis.
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NHLBI 工作组关于降低脂蛋白 (a) 介导的心血管疾病和主动脉瓣狭窄风险的建议。
DOI：
10.1016/j.jacc.2017.11.014
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发表时间：
2018-01-16
影响因子：
24
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Tsimikas S;Fazio S;Ferdinand KC;Ginsberg HN;Koschinsky ML;Marcovina SM;Moriarty PM;Rader DJ;Remaley AT;Reyes-Soffer G;Santos RD;Thanassoulis G;Witztum JL;Danthi S;Olive M;Liu L
病理生理学、流行病学和遗传学研究提供了强有力的证据，表明Lp（a）是心血管疾病（CVD）和钙化性主动脉瓣疾病（CAVD）的致病介质。治疗Lp（a）介导的CVD和CAVD的特定疗法正在临床开发中。由于知识差距，国家心脏，肺和血液研究所（NHLBI）组织了一个工作组（WG），确定了充分理解Lp（a）在CVD/CAVD中作用的挑战。这些问题包括缺乏研究资金、实验模型不足、缺乏全球标准化的Lp（a）检测以及对目前药物治疗对Lp（a）水平的作用机制了解不足。提供了具体的建议，以促进Lp（a）的基础，机制，临床前和临床研究，促进合作研究和资源共享，利用具有互补技能的不同团体和中心的专业知识，并利用现有的NHLBI资源。需要共同努力了解Lp（a）病理生理学，以及诊断和治疗进展，以降低Lp（a）介导的CVD和CAVD风险。
Pathophysiological, epidemiologic and genetic studies provide strong evidence that Lp(a) is a causal mediator of cardiovascular disease (CVD) and calcific aortic valve disease (CAVD). Specific therapies to address Lp(a)-mediated CVD and CAVD are in clinical development. Due to knowledge gaps, the National Heart, Lung, and Blood Institute (NHLBI) organized a Working Group (WG) that identified challenges in fully understanding the role of Lp(a) in CVD/CAVD. These included the lack of research funding, inadequate experimental models, lack of globally standardized Lp(a) assays and inadequate understanding of the mechanisms underlying current drug therapies on Lp(a) levels. Specific recommendations were provided to facilitate basic, mechanistic, preclinical, and clinical research on Lp(a), foster collaborative research and resource sharing, leverage expertise of different groups and centers with complementary skills, and utilize existing NHLBI resources. Concerted efforts to understand Lp(a) pathophysiology, together with diagnostic and therapeutic advances, are required to reduce Lp(a)-mediated risk of CVD and CAVD.
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影响因子：
120.7
作者：
Erqou, Sebhat;Kaptoge, Stephen;Perry, Philip L.;Di Angelantonio, Emanuele;Thompson, Alexander;White, Ian R.;Marcovina, Santica M.;Collins, Rory;Thompson, Simon G.;Danesh, John
通讯作者：
Danesh, John
影响因子：
37.8
作者：
Khera AV;Everett BM;Caulfield MP;Hantash FM;Wohlgemuth J;Ridker PM;Mora S
通讯作者：
Mora S
影响因子：
6.2
作者：
Anderson, Todd J.;Gregoire, Jean;Ward, Richard
通讯作者：
Ward, Richard
影响因子：
24
作者：
Capoulade, Romain;Chan, Kwan L.;Tsimikas, Sotirios
通讯作者：
Tsimikas, Sotirios
影响因子：
24
作者：
Kamstrup, Pia R.;Tybjaerg-Hansen, Anne;Nordestgaard, Borge G.
通讯作者：
Nordestgaard, Borge G.