Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging
Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging
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DOI：
10.1016/j.atherosclerosis.2006.08.016
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发表时间：
2007-10-01
期刊：
影响因子：
5.3
通讯作者：
Hatsukami, Thomas S.
中科院分区：
文献类型：
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作者：
Saam, Tobias;Yuan, Chun;Hatsukami, Thomas S.
这项体内MRI研究的目的是前瞻性地量化动脉粥样硬化斑块形态的变化，并确定可能改变斑块负荷进展速度的因素。68例狭窄≥ 50%的无症状受试者在18个月内接受了一系列颈动脉MRI检查。前瞻性记录动脉粥样硬化的临床危险因素和药物治疗。从横截面图像测量跨时间点匹配的壁和总血管面积。在基线和18个月时记录标准化血管壁指数（NWI =血管壁面积/总血管面积），作为疾病严重程度的标志物。采用多元回归分析将危险因素和斑块的形态特征与进展/消退率相关联，平均而言，壁面积每年增加2.2%（P = 0.001）。多元回归分析表明，他汀类药物治疗（P = 0.01）和标准化室壁指数>0.64（P = 0.001）与平均室壁面积进展率显著降低相关。所有其他记录的风险因素与室壁面积的变化无显著相关性。这项研究的结果表明，在晚期无症状颈动脉粥样硬化患者中，标准化血管壁指数增加和他汀类药物治疗的使用与斑块进展率降低相关。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
The purpose of this in vivo MRI study was to quantify changes in atherosclerotic plaque morphology prospectively and to identify factors that may alter the rate of progression in plaque burden. Sixty-eight asymptomatic subjects with >= 50% stenosis, underwent serial carotid MRI examinations over an 18-month period. Clinical risk factors for atherosclerosis, and medications were documented prospectively. The wall and total vessel areas, matched across time-points, were measured from cross-sectional images. The normalized wall index (NWI = wall area/total vessel area), as a marker of disease severity, was documented at baseline and at 18 months. Multiple regression analysis was used to correlate risk factors and morphological features of the plaque with the rate of progression/regression.On average, the wall area increased by 2.2% per year (P = 0.001). Multiple regression analysis demonstrated that statin therapy (P = 0.01) and a normalized wall index >0.64 (P = 0.001) were associated with a significantly reduced rate of progression in mean wall area. All other documented risk factors were not significantly associated with changes in wall area. Findings from this study suggest that increased normalized wall index and the use of statin therapy are associated with reduced rates of plaque progression amongst individuals with advanced, asymptomatic carotid atherosclerosis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.