Red blood cell distribution width and neutrophil to lymphocyte ratio are correlated with disease activity of dermatomyositis and polymyositis
Red blood cell distribution width and neutrophil to lymphocyte ratio are correlated with disease activity of dermatomyositis and polymyositis
复制标题
红细胞分布宽度和中性粒细胞与淋巴细胞比值与皮肌炎和多发性肌炎的疾病活动度相关
DOI：
10.1002/jcla.22209
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发表时间：
2018-01-01
影响因子：
2.7
通讯作者：
Ren, Tian-Li
中科院分区：
文献类型：
--
作者：
Gao, Ming-Zhu;Huang, Yuan-Lan;Ren, Tian-Li
背景研究表明，红细胞分布宽度（RDW）和中性粒细胞/淋巴细胞比值（NLR）是评价自身免疫性疾病活动性的有用指标。然而，RDW，NLR和皮肌炎（DM）和多发性肌炎（PM）之间的联系的证据是有限的。方法回顾性分析114例PM/DM患者和114例健康对照者的病历资料，提取入院时的RDW、NLR和肌炎疾病活动度视觉模拟评分（MYOACT）。采用斯皮尔曼方法和多变量模型分析RDW、NLR和MYOACT之间的相关性。PM/DM患者RDW的增加并不完全归因于血红蛋白或治疗药物的减少。RDW和NLR均与MYOACT呈独立正相关。结论RDW和NLR均是评价PM/DM病情活动性的有用指标。
BackgroundPrevious studies indicated that both red blood cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) were useful indices in assessing the disease activity of autoimmune diseases. However, the evidence for the association between RDW, NLR and dermatomyositis (DM) and polymyositis (PM) is limited. The aim of this study is to investigate the association between the disease activity of PM/DM and both RDW and NLR.MethodsMedical records of 114 PM/DM patients and 114 healthy controls were retrospectively reviewed, and their RDW, NLR and myositis disease activity assessment visual analogue scale (MYOACT) on admission were extracted. The correlations between RDW, NLR and MYOACT were analyzed using the Spearman approach and multivariable model.ResultsPM/DM patients had significantly higher RDW and NLR. Increased RDW in PM/DM patients was not completely attributed to decreased hemoglobin or therapeutic agents. Both RDW and NLR are independently and positively correlated MYOACT.ConclusionBoth RDW and NLR are useful indices in assessing the disease activity of PM/DM.