Genetic pathways regulating glutamate levels in retinal Müller cells.
Genetic pathways regulating glutamate levels in retinal Müller cells.
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DOI：
10.1007/s11064-010-0277-1
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发表时间：
2011-04
影响因子：
4.4
通讯作者：
Geisert, Eldon E.
中科院分区：
文献类型：
--
作者：
Jablonski, Monica M.;Freeman, Natalie E.;Orr, William E.;Templeton, Justin P.;Lu, Lu;Williams, Robert W.;Geisert, Eldon E.
关键词：
Müller细胞具有许多功能，包括调节细胞外谷氨酸水平。两个基因的产物Slc1a3 [又名溶质载体家族1（神经胶质高亲和力谷氨酸转运蛋白），成员3]和Glul（又名谷氨酰胺合成酶）是将谷氨酸转运到Müller细胞并将其转化为谷氨酰胺的主要角色。在这项研究中，我们试图确定这两个基因的遗传调控。考虑到它们紧密耦合的生物学功能，我们预测它们将受到类似的调控。使用75个重组近交系小鼠阵列，我们确定Slc 1a 3和Glul受到不同染色体区域的差异调节。有趣的是，尽管它们是独立调控的，但紧密相关基因的基因本体论分析显示，两个有向无环图的富集和统计学显著的分子功能类别具有大量重叠，表明Slc1a3和Glul的相关物的共享功能包括ATP的产生和使用。
Müller cells serve many functions including the regulation of extracellular glutamate levels. The product of two genes, Slc1a3 [aka solute carrier family 1 (glial high affinity glutamate transporter), member 3] and Glul (aka glutamine synthetase) are the primary role players that transport glutamate into the Müller cell and convert it into glutamine. In this study, we sought to identify the genetic regulation of both genes. Given their tightly coupled biological functions, we predicted that they would be similarly regulated. Using an array of 75 recombinant inbred strains of mice, we determined that Slc1a3 and Glul are differentially regulated by distinct chromosomal regions. Interestingly, despite their independent regulation, gene ontology analysis of tightly correlated genes reveals that the enriched and statistically significant molecular function categories of both directed acyclic graphs have substantial overlap, indicating that the shared functions of correlates of Slc1a3 and Glul include production and usage of ATP.
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影响因子：
64.8
作者：
KANAI, Y;HEDIGER, MA
通讯作者：
HEDIGER, MA
影响因子：
4.2
作者：
Gegelashvili, Marina;Rodriguez-Kern, Anna;Gegelashvili, Georgi
通讯作者：
Gegelashvili, Georgi
影响因子：
64.8
作者：
BOUVIER, M;SZATKOWSKI, M;ATTWELL, D
通讯作者：
ATTWELL, D
影响因子：
30.8
作者：
Chesler, EJ;Lu, L;Williams, RW
通讯作者：
Williams, RW
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y