A genetic map of the mouse suitable for typing intraspecific crosses.
A genetic map of the mouse suitable for typing intraspecific crosses.
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适合进行种内杂交分型的小鼠遗传图谱。
DOI：
10.1093/genetics/131.2.423
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发表时间：
1992
期刊：
影响因子：
3.3
通讯作者：
Lander,ES
中科院分区：
文献类型：
--
作者：
Dietrich,W;Katz,H;Lincoln,SE;Shin,HS;Friedman,J;Dracopoli,NC;Lander,ES
我们报道了小鼠遗传连锁图谱的构建，该图谱完全由可以通过聚合酶链式反应快速分型的遗传标记组成，并且在近亲交配的实验室菌株中显示出高度的多态。具体地说，该图谱包含317个平均间距为4.3 cM的简单序列长度多态，并可检测到与大约99%的小鼠基因组相关联。在实验室自交系之间的典型杂交中，大约50%的标记是多态的，这使得几乎在任何杂交中都可以直接跟踪遗传。
We report the construction of a genetic linkage map of the mouse, consisting entirely of genetic markers that can be rapidly typed by polymerase chain reaction and that show a high degree of polymorphism among inbred laboratory strains. Specifically, the map contains 317 simple sequence length polymorphisms at an average spacing of 4.3 cM and is detectably linked to approximately 99% of the mouse genome. In typical crosses between inbred laboratory strains, about 50% of the markers are polymorphic, making it straightforward to follow inheritance in almost any cross.