White blood cell count and abdominal fat distribution in female obese adolescents
White blood cell count and abdominal fat distribution in female obese adolescents
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DOI：
10.1016/j.metabol.2008.05.005
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发表时间：
2008-10-01
影响因子：
9.8
通讯作者：
Park, Hye Soon
中科院分区：
文献类型：
--
作者：
Kim, Jeong A.;Park, Hye Soon
腹部脂肪分布与炎症标志物之间的关系目前是一个有争议的话题。在这里，我们描述的关系白细胞（WBC）计数和腹部脂肪分布的女性肥胖青少年。对102名女性肥胖青少年进行分析。测量了人体测量、白细胞计数、血压、空腹血糖、血脂和空腹胰岛素浓度。使用计算机断层扫描计算皮下脂肪组织（SAT）和内脏脂肪组织面积。WBC越高，腰围平均值（P < 0.05）、总脂肪组织（TAT）平均值（P < 0.01）、SAT平均值（P < 0.01）越高。调整年龄和代谢危险因素后，WBC计数与体重指数、腰围、TAT和SAT面积呈正相关（P < 0.01）。白细胞组成成分中，中性粒细胞与体重指数（P < 0.01）、腰围（P < 0.01）、TAT （P < 0.05）呈正相关。WBC计数随着TAT或SAT的分级升高而升高（P < 0.01）。我们的研究结果共同表明，白细胞计数与女性肥胖青少年腹部肥胖呈正相关。此外，这种关系在皮下脂肪比内脏脂肪更容易区分。(C) 2008爱思唯尔公司版权所有。
The association between abdominal fat distribution and inflammatory markers is currently a subject of debate. Here, we delineate the relationship between white blood cell (WBC) counts and abdominal fat distribution in female obese adolescents. A total of 102 female obese adolescent subjects were analyzed. Anthropometry, WBC count, blood pressure, fasting plasma glucose, lipid profiles, and fasting insulin concentrations were measured. Subcutaneous adipose tissue (SAT) and visceral adipose tissue areas were calculated using computed tomography. Mean values of waist circumference (P < .05), total adipose tissue (TAT) (P < .01), and SAT (P < .01) were significantly higher in the group with the higher WBC count. The WBC count was positively related to body mass index, waist circumference, and TAT and SAT areas after adjustment for age and metabolic risk factors (P < .01). Among the WBC components, neutrophils were positively associated with body mass index (P < .01), waist circumference (P < .01), and TAT (P < .05). The WBC count escalated with a graded increase in TAT or SAT (P for trend < .01). Our findings collectively indicate that the WBC count is positively related to abdominal adiposity in female obese adolescents. Moreover, this relationship is more distinguishable with subcutaneous than visceral adiposity. (C) 2008 Elsevier Inc. All rights reserved.