Fluorescence in situ hybridization status of voided urine predicts invasive and high-grade upper tract urothelial carcinoma
Fluorescence in situ hybridization status of voided urine predicts invasive and high-grade upper tract urothelial carcinoma
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排泄尿液的荧光原位杂交状态可预测侵袭性和高级别上尿路尿路上皮癌
DOI：
10.18632/oncotarget.15344
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Zhou Liqun
中科院分区：
文献类型：
--
作者：
Su Xiaohong;Hao Han;Li Xuesong;He Zhisong;Gong Kan;Zhang Cuijian;Cai Lin;Zhang Qian;Yao Lin;Ding Yi;Gong Yanqing;Fang Dong;Zhang Zheng;Zhou Liqun
在这里，我们评估了荧光原位杂交（FISH）检测侵袭性上尿路尿路上皮癌（UTUC）的诊断准确性。这项回顾性研究于2012年至2016年间招募了来自中国一家医院的总计210名UTUC患者。根据尿液FISH分析结果将患者分为FISH阳性和阴性两组，比较两组患者的临床病理特征。FISH结果阳性的患者比阴性的患者有更晚期的肿瘤分期和更高的肿瘤分级。FISH检测晚期UTUC的总敏感性为62.4%（131/210）。FISH阳性结果的敏感性和阳性预测值分别为76.5%和59.5%的高度UTUC和71.7%和58.0%的肌层浸润性UTUC。这些数据表明，排尿FISH结果准确地预测先进的UTUC，并可能有助于区分患者的侵袭性疾病，从那些可能受益于保守的管理。
Here, we assessed the diagnostic accuracy of fluorescence in situ hybridization (FISH) for detecting aggressive upper tract urothelial carcinoma (UTUC). A total of 210 UTUC patients from a single hospital in China were enrolled in this retrospective study between 2012 and 2016. Patients were classified as FISH-positive or -negative based on FISH analysis of voided urine, and the clinicpathological characteristics of these two patient groups were compared. Patients with positive FISH results had more advanced tumor stages and higher tumor grades than those with negative results. The overall sensitivity of FISH for detecting advanced UTUC was 62.4% (131/210). The sensitivity and positive predictive values of positive FISH results were 76.5% and 59.5% for high-grade UTUC and 71.7% and 58.0% for muscle-invasive UTUC. These data suggest that voided urine FISH results accurately predict advanced UTUC and might help distinguish patients with aggressive disease from those who might benefit from conservative management.
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DOI：
10.1016/j.urolonc.2011.12.021
发表时间：
2013-10-01
影响因子：
2.7
作者：
Straub, Julia;Strittmatter, Frank;Tritschler, Stefan
通讯作者：
Tritschler, Stefan
影响因子：
4.5
作者：
Messer, Jamie;Shariat, Shahrokh F.;Raman, Jay D.
通讯作者：
Raman, Jay D.
DOI：
--
发表时间：
1993-05
期刊：
The Urologic clinics of North America
影响因子：
--
作者：
Melamed Mr;Reuter Ve
通讯作者：
Melamed Mr;Reuter Ve
影响因子：
6.6
作者：
Johannes, James R.;Nelson, Eric;Bagley, Demetrius H.
通讯作者：
Bagley, Demetrius H.
影响因子：
3.2
作者：
Lee, Jung Keun;Kim, Ki Bom;Lee, Sang Eun
通讯作者：
Lee, Sang Eun