Neurometabolites in schizophrenia and bipolar disorder - a systematic review and meta-analysis.
Neurometabolites in schizophrenia and bipolar disorder - a systematic review and meta-analysis.
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精神分裂症和双相情感障碍的神经代谢物 - 系统评价和荟萃分析。
DOI：
10.1016/j.pscychresns.2012.02.003
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发表时间：
2012-08
影响因子：
11.3
通讯作者：
Lahti AC
中科院分区：
文献类型：
--
作者：
Kraguljac NV;Reid M;White D;Jones R;den Hollander J;Lowman D;Lahti AC
本荟萃分析评价精神分裂症和双相情感障碍中神经代谢物的改变。检索PubMed，以查找截至2010年9月在精神分裂症和双相情感障碍患者中使用1H-MRS（质子磁共振波谱）评估N-乙酰天冬氨酸（NAA）、胆碱（Cho）和肌酸（Cr）的对照研究。进行随机效应荟萃分析，以估计合并的标准化平均差异。使用I2统计量来量化不一致性。进行了亚组分析，以探索不一致的潜在解释。146项研究，5643名受试者被纳入系统综述。NAA水平在精神分裂症和双相情感障碍中受到影响。基底神经节和额叶水平降低是精神分裂症中最一致的结果，基底神经节水平降低是双相情感障碍中最一致的结果。Cho和Cr水平在两种疾病中均未改变。在精神分裂症患者的丘脑、额叶和背外侧前额叶皮质以及双相情感障碍患者的基底神经节和额叶中，Cr的结果最为一致。Cho在精神分裂症患者的丘脑、额叶和前扣带皮层以及双相情感障碍患者的基底神经节中的发现最为一致。需要进行大规模的、精心设计的研究，以更好地估计神经代谢物改变的程度。
This meta-analysis evaluates alterations of neurometabolites in schizophrenia and bipolar disorder. PubMed was searched to find controlled studies evaluating N-acetylaspartate (NAA), Choline (Cho) and Creatine (Cr) assessed with 1H-MRS (proton magnetic resonance spectroscopy) in patients with schizophrenia and bipolar disorder up to September 2010. Random effects meta-analyses were conducted to estimate pooled standardized mean differences. I2 statistic was used to quantify inconsistencies. Subgroup analyses were conducted to explore potential explanations for inconsistencies. 146 studies with 5643 participants were included in the systematic review. NAA levels were affected in schizophrenia and bipolar disorder. Decreased levels in the basal ganglia and frontal lobe were the most consistent findings in schizophrenia, decreased levels in the basal ganglia were the most consistent findings in bipolar disorder. Cho and Cr levels were not altered in either disorder. Findings for Cr were most consistent in the thalamus, frontal lobe and dorsolateral prefrontal cortex in schizophrenia and the basal ganglia and frontal lobe in bipolar disorder. Findings for Cho were most consistent in the thalamus, frontal lobe and anterior cingulate cortex in schizophrenia and basal ganglia in bipolar disorder. Large, carefully designed studies are needed to better estimate the extent of alterations in neurometabolites.