Altered brain copper and zinc content in quaking mice.
Altered brain copper and zinc content in quaking mice.
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改变了颤抖小鼠的脑铜和锌含量。
DOI：
10.1016/0014-4886(83)90242-x
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发表时间：
1983
影响因子：
5.3
通讯作者：
FriedrichJr,VL
中科院分区：
文献类型：
--
作者：
Rosenfeld,J;Zimmerman,AW;FriedrichJr,VL
在21日龄和“成年”C3 HeB FeJ震颤小鼠和正常同窝对照组中测定脑铜和锌水平。以每克脑干重表示，出生后21天，铜比正常小鼠增加84%，但与成年小鼠无显著差异。锌在两个年龄段都增加了23%至24%。在这两个年龄段，来自颤抖小鼠的大脑中固体含量显着减少，表明突变体大脑中的水含量增加。我们的研究是第一个报告铜和锌含量作为衡量脑湿重和脑干重的指标。我们的研究结果表明，异常铜含量的震动突变体。铜含量与震颤表型的其他方面，包括其癫痫发作行为和髓鞘缺陷之间的关系仍有待建立。
Brain copper and zinc levels were determined in 21-day-old and “adult” C 3 HeB FeJ quaking mice and in normal littermate controls. Expressed per gram dry weight of brain, copper was increased 84% over normal mice at 21 days after birth, but was not significantly different from normal in the adults. Zinc was increased 23 to 24% at both ages. At both ages, brains from quaking mice had a significantly reduced content of solids, indicating increased water content in the mutant brain. Our study is the first to report copper and zinc content as a measure of both wet and dry brain weights. Our results indicate abnormal copper content in the quaking mutant. The relationship between copper content and other aspects of the quaking phenotype, including its seizure behavior and myelin deficit, remain to be established.