Functional significance of striatal responses during episodic decisions: recovery or goal attainment?
Functional significance of striatal responses during episodic decisions: recovery or goal attainment?
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DOI：
10.1523/jneurosci.3077-09.2010
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发表时间：
2010-03-31
期刊：
影响因子：
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通讯作者：
Dobbins IG
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文献类型：
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作者：
Han S;Huettel SA;Raposo A;Adcock RA;Dobbins IG
记忆检索通常是一种目标导向的行为，因此可能受到强化和动机过程的影响。尽管纹状体激活在记忆检索过程中通常很明显，但其功能意义仍不清楚，因为典型的记忆范式不能控制记忆决策的动机意义。我们使用事件相关的功能磁共振成像（fMRI）来研究在有或没有与表现相关的金钱激励的情况下识别过程中纹状体的激活。在缺乏激励的初始表现中，“旧”记忆结论的背侧纹状体激活仍然超过了“新”结论，无论这些结论的准确性如何。相比之下，随后的扫描将激励措施与“旧”或“新”结论配对，并显示出对任何可能获得奖励的判断的更大激活，无论是否有绩效反馈。数据表明，识别判断过程中纹状体的激活并不表示金钱奖励的收到、认知反馈或成功的情景检索。相反，它在很大程度上取决于观察者主观目标的满足程度。
Memory retrieval is typically a goal-directed behavior, and as such, potentially influenced by reinforcement and motivation processes. Although striatal activation is often evident during memory retrieval, its functional significance remains unclear because typical memory paradigms do not control the motivational significance of memory decisions. We used event-related functional magnetic resonance imaging (fMRI) to investigate striatal activation during recognition with and without performance-linked monetary incentives. During initial performance in the absence of incentives, dorsal striatal activation for “Old” memory conclusions nonetheless exceeded that for “New” conclusions irrespective of the accuracy of these conclusions. In contrast, subsequent scans paired incentives with either “Old” or “New” conclusions and demonstrated greater activation for whichever judgment was potentially rewarded, both with and without performance feedback. The data demonstrate that striatal activation during recognition judgments does not signal monetary reward receipt, cognitive feedback, or successful episodic retrieval. Instead, it is heavily dependent upon satisfaction of the subjective goals of the observer.