Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy.
Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy.
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DOI：
10.1016/s0140-6736(12)61031-9
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发表时间：
2012-07-21
期刊：
影响因子：
168.9
通讯作者：
Katzmarzyk, Peter T.
中科院分区：
文献类型：
--
作者：
Lee, I-Min;Shiroma, Eric J.;Lobelo, Felipe;Puska, Pekka;Blair, Steven N.;Katzmarzyk, Peter T.
强有力的证据表明，缺乏身体活动会增加许多不良健康状况的风险，包括世界上主要的非传染性疾病，如冠心病、2型糖尿病、乳腺癌和结肠癌，并缩短预期寿命。由于世界上大部分人口不活跃，这就构成了一个重大的公共卫生问题。我们的目标是量化缺乏身体活动对这些主要非传染性疾病的影响，方法是估计如果那些不活动的人变得活跃，可以避免多少疾病，并估计人口预期寿命的增加。使用保守的假设，我们计算了每个国家与主要NCD的身体活动相关的人口归因分数（PAF），以估计如果消除身体活动，可以避免多少疾病，并使用寿命表分析来估计人口预期寿命的增加。在全球范围内，我们估计，缺乏身体活动导致6%的冠心病疾病负担（范围：东南亚3.2%至东地中海地区7.8%）; 7%的2型糖尿病（3.9%至9.6%），10%的乳腺癌（5.6%至14.1%）和10%的结肠癌（5.7%至13.8%）。不活动导致9%的过早死亡（5.1%至12.5%），或2008年全球5700万例死亡中的5.3%。如果不消除不活动，而是减少10%或25%，每年可分别避免533，000和130万人死亡。通过消除缺乏身体活动，世界人口的预期寿命估计将增加0.68岁（0.41至0.95岁）。缺乏身体活动对世界健康有重大影响。消除身体不活动将消除6%至10%的主要非传染性疾病，如冠心病、2型糖尿病、乳腺癌和结肠癌，并延长预期寿命。
Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including the world’s major non-communicable diseases (NCDs) of coronary heart disease (CHD), type 2 diabetes, and breast and colon cancers, and shortens life expectancy. Because much of the world’s population is inactive, this presents a major public health problem. We aimed to quantify the impact of physical inactivity on these major NCDs by estimating how much disease could be averted if those inactive were to become active and to estimate gain in life expectancy, at the population level. Using conservative assumptions, we calculated population attributable fractions (PAF) associated with physical inactivity for each of the major NCDs, by country, to estimate how much disease could be averted if physical inactivity were eliminated, and used life table analysis to estimate gains in life expectancy of the population. Worldwide, we estimate that physical inactivity is responsible for 6% of the burden of disease from CHD (range: 3.2% in South-east Asia to 7.8% in the Eastern Mediterranean region); 7% of type 2 diabetes (3.9% to 9.6%), 10% of breast cancer (5.6% to 14.1%), and 10% of colon cancer (5.7% to 13.8%). Inactivity is responsible for 9% of premature mortality (5.1% to 12.5%), or >5.3 of the 57 million deaths that occurred worldwide in 2008. If inactivity were not eliminated, but decreased instead by 10% or 25%, >533,000 and >1.3 million deaths, respectively, may be averted each year. By eliminating physical inactivity, life expectancy of the world’s population is estimated to increase by 0.68 (0.41 to 0.95) years. Physical inactivity has a major health impact on the world. Elimination of physical inactivity would remove between 6% and 10% of the major NCDs of CHD, type 2 diabetes, and breast and colon cancers, and increase life expectancy.