Intracervical elastomeric sealant in an ex vivo model.
Intracervical elastomeric sealant in an ex vivo model.
复制标题
离体模型中的宫颈内弹性密封剂。
DOI：
10.1080/14767058.2019.1626367
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Mandai M.
中科院分区：
文献类型：
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作者：
Kondoh E;Kawamura Y;Chigusa Y;Mogami H;Ueda A;Hamanishi J;Mandai M.
背景在可预见的中期妊娠患者中发生的胎膜早破与围生儿死亡率相关，最佳的治疗方法尚未建立。本研究的目的是调查弹性密封剂是否已被用作动脉吻合术的止血剂，方法应用弹性胶或纤维蛋白胶，在人工子宫模型上填塞子宫颈管，4例因妇科良性疾病行宫颈切除术。用压力输液袋通过导管将生理盐水注入离体子宫腔。使用数字压力计测量子宫内压力，并在生理盐水开始泄漏的子宫颈的压力进行了比较between both sealings.ResultsNo液体泄漏观察与弹性密封剂，直到压力超过20 kPa（150 mmHg），而泄漏的起始压力与纤维蛋白密封剂为6.6 ± 1.8 kPa（50 ± 14 mmHg）。两种密封剂之间液体流动开始的阈值泄漏压力显著不同（p<0.0001）。这种密封剂有可能防止有胎膜早破的孕妇羊水渗漏。
BackgroundPremature rupture of membranes occurring in previable midtrimester patients is associated with perinatal mortality, and optimal therapeutic methods are yet to be established.ObjectiveThis study’s objective was to investigate whether an elastomeric sealant, which has been used as a hemostatic agent for arterial anastomosis, could plug the uterine endocervical canal to prevent leakage of intrauterine fluid in anex vivomodel.MethodsThe elastomeric sealant or fibrin glue was applied to the cervix of uteri removed for benign gynecological disease (n= 4). Normal saline was administered into theex vivouterine cavity through a catheter using a pressure infusion bag. Intrauterine pressure was measured using a digital pressure gauge, and the pressure at which normal saline started leaking out of the uterine cervix was compared between both the sealants.ResultsNo fluid leakage was observed with the elastomeric sealant until the pressure exceeded 20 kPa (150 mmHg), while the leakage onset pressure with fibrin sealant was 6.6 ± 1.8 kPa (50 ± 14 mmHg). The threshold leak pressure where the onset of liquid flow was initiated was significantly different between both the sealants (p< .0001).ConclusionsIntracervical elastomeric sealant exhibited powerful fluid leakage prevention in anex vivomodel. The sealant would have potential to prevent the leakage of amniotic fluid in pregnancies with previable premature rupture of membranes.