COMPARISON OF THE EFFECTS OF DRY AND LIQUID HEPARIN ON NEONATAL ARTERIAL BLOOD-GASES
COMPARISON OF THE EFFECTS OF DRY AND LIQUID HEPARIN ON NEONATAL ARTERIAL BLOOD-GASES
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DOI：
10.1055/s-2007-999311
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发表时间：
1992-05-01
影响因子：
2
通讯作者：
DOLANSKI, EA
中科院分区：
文献类型：
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作者：
GAYED, AM;MARINO, ME;DOLANSKI, EA
我们比较了液体和蒸发干燥肝素对新生儿动脉血气的影响。共收集了35对同时抽取的新生儿动脉血样本。在每对样品中的一个中，使用0.05 cc液体肝素，在另一个样品中使用汽化肝素注射器。将血液抽入每个注射器中至总体积为0.2 ml，使用配对Student t方法分析配对样本的pH、动脉氧分压（PaO2）和动脉二氧化碳分压（PaCO2）。pH和PaO2无统计学差异，但液体肝素组PaCO2在统计学上较低（p < 0.0005）。我们得出结论，肝素对新生儿动脉血气的影响本质上是稀释性的，这是由于肝素与其极低的PaCO2与血液样本混合所致。如果错误地使用了超过必要的肝素，其影响可能是戏剧性的。因此，我们建议在获取新生儿动脉血气时使用含汽化肝素的注射器，以获得可靠和一致的结果。
We compared the effects of liquid and vaporized dry heparin on neonatal arterial blood gases. A total of 35 paired simultaneously drawn neonatal arterial blood samples were collected. In one of every paired sample, 0.05 cc of liquid heparin was used and in the other sample vaporized heparin syringes were used. Blood was drawn into every syringe to a total volume of 0.2 ml, pH, arterial oxygen tension (PaO2), and arterial carbon dioxide tension (PaCO2) of the paired samples were analyzed using the paired Student t method. There was no statistical difference in pH and PaO2 but the PaCO2 was statistically lower (p < 0.0005) with liquid heparin. We conclude that the effects of heparin on neonatal arterial blood gases is dilutional in nature and that they are due to mixing heparin with its very low PaCO2 with the blood sample. If by mistake more heparin than necessary is used, the effects can be dramatic. We therefore suggest using syringes with vaporized heparin in obtaining neonatal arterial blood gases to obtain reliable and consistent results.