Regulatory factors of basal F2-isoprostane formation: Population, age, gender and smoking habits in humans
Regulatory factors of basal F2-isoprostane formation: Population, age, gender and smoking habits in humans
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DOI：
10.1080/10715760802610851
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发表时间：
2009-01-01
影响因子：
3.3
通讯作者：
Barregard, Lars
中科院分区：
文献类型：
--
作者：
Basu, Samar;Helmersson, Johanna;Barregard, Lars
氧化应激被认为是许多常见疾病发病的关键潜在因素。这项研究描述了来自意大利、波兰和瑞典三个国家的健康受试者体内8-iso-PGF2的基础水平与他们的吸烟习惯、年龄和性别的关系。8-iso-PGF2是一种主要的F2-异前列腺素和体内氧化应激生物标志物。它研究了来自瑞典(n=220)、意大利(n=203)和波兰(n=165)的588名受试者的尿8-iso-PGF2。在对吸烟、年龄、性别和肌酐进行调整后，波兰人的F2-异前列腺素水平最高，瑞典人和意大利人次之，而且国家间的差异具有统计学意义。在所有国家中，吸烟者的8-iso-PGF2水平明显高于不吸烟者，并且随着年龄的增长略有下降。女性的8-iso-PGF2仅略低于男性。不同国家体内的F2-异前列腺素水平存在差异。吸烟、年龄和性别会影响异前列腺素的形成，在氧化应激的临床研究中应予以考虑。
Oxidative stress is assumed to be the key underlying factor in the pathogenesis of many common diseases. This study describes the basal levels of 8-iso-PGF2 , a major F2-isoprostane and an in vivo oxidative stress biomarker in healthy subjects from three countries, namely Italy, Poland and Sweden, in relation to their smoking habits, age and gender. It studied urinary 8-iso-PGF2 in 588 subjects from Sweden (n=220), Italy (n=203) and Poland (n=165). Polish subjects had the highest levels of F2-isoprostanes followed by the Swedish and Italians when adjusted for smoking, age, sex and creatinine and the inter-country differences were statistically significant. Smokers had significantly higher levels of 8-iso-PGF2 compared to non-smokers in all countries and there was a moderate decrease with age. Women had only slightly lower 8-iso-PGF2 than men. There is a difference in F2-isoprostane levels in vivo between countries. Smoking, age and gender affect isoprostane formation and should be taken into consideration in clinical studies of oxidative stress.