The HLA Class II Associations with Rheumatic Heart Disease in South Indian Patients: A Preliminary Study
The HLA Class II Associations with Rheumatic Heart Disease in South Indian Patients: A Preliminary Study
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DOI：
10.7860/jcdr/2013/4509.2752
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发表时间：
2013-02-01
影响因子：
0.2
通讯作者：
Menon, Thangam
中科院分区：
文献类型：
--
作者：
Bajoria, Divya;Menon, Thangam
Introduction: Rheumatic heart disease (RHD) occurs in 30-45% of the patients with rheumatic fever (RF) and it leads to chronic valvular lesions. The human leukocyte antigen (HLA) might confer a susceptibility to RHD. The aim of the present study was to determine the prevalent HLA class II DR/DO allelic types which were associated with rheumatic heart disease (RHD) in a small group of south Indian patients and to compare them with those in the control subjects.Methods: A total of 23 patients who were diagnosed with RHD and 6 control samples were included in this study. A low resolution HLA Class II DR/DO typing was performed on the blood samples by the PCR-SSP method. Results andConclusion: The DRBX01:01:02:01 allele showed a positive association with RHD, whereas the DQB1 loci alleles did not show any significant association.
