Is Human Papilloma Virus Infection Linked to Periodontitis? A Narrative Review.
Is Human Papilloma Virus Infection Linked to Periodontitis? A Narrative Review.
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DOI：
10.1007/s40496-019-0206-6
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发表时间：
2019-03
影响因子：
--
通讯作者：
Pérez CM
中科院分区：
文献类型：
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作者：
Ortiz AP;Ramos-Cartagena JM;García-Camacho SI;Andriankaja OM;Pérez CM
研究表明，牙周组织可能是口腔人类乳头瘤病毒(HPV)感染的蓄水池，而另一种假设是，该组织的慢性炎症可能会使口腔HPV感染的感染持续下去。在这篇叙述性综述中，我们总结了与口腔HPV感染和牙周炎之间潜在关联的证据。确定了12篇文章，并总结了它们的主要发现。研究在样本量、研究人群、研究设计和评估口腔HPV和牙周炎的方法上各不相同。虽然结果相互矛盾，仍然没有定论，但各种研究已经发现口腔HPV感染和牙周炎之间存在联系，这一点得到了生物学上的支持。未来的纵向研究应该进一步评估这种联系，使用口腔HPV感染和牙周炎的临床定义，并将重点放在口腔HPV感染的高危人群上。研究这种联系很重要，因为牙周炎可能有助于确定口腔HPV感染和潜在的HPV相关口咽癌的高危个体。
Research suggests that periodontal tissue might serve as a reservoir for oral human papillomavirus (HPV) infection, while another hypothesis is that chronic inflammation of the tissue might perpetuate an infection with oral HPV infection. In this narrative review, we summarize the evidence related to a potential association between oral HPV infection and periodontitis. Twelve articles were identified, and their key findings summarized. Studies vary in sample size, study population, study design, and methods for assessment of oral HPV and periodontitis. Although results are conflicting and still inconclusive, various studies have found an association between oral HPV infection and periodontitis, which is supported by biological plausibility. Future longitudinal studies should further evaluate this association, using clinical definitions of oral HPV infection and periodontitis, and focusing on high-risk populations for oral HPV infection. Studying this association is important since periodontitis might help identify at-risk individuals for oral HPV infection and potentially HPV-related oropharyngeal cancers