SPECIES VARIATION IN THE STRUCTURE AND FUNCTION OF THE MARGINAL ZONE - AN ELECTRON-MICROSCOPE STUDY OF CAT SPLEEN
SPECIES VARIATION IN THE STRUCTURE AND FUNCTION OF THE MARGINAL ZONE - AN ELECTRON-MICROSCOPE STUDY OF CAT SPLEEN
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DOI：
10.1002/aja.1001610204
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发表时间：
1981-01-01
影响因子：
--
通讯作者：
WEISS, L
中科院分区：
文献类型：
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作者：
BLUE, J;WEISS, L
猫脾的边缘地带由淋巴细胞和其他血细胞的典型混合物组成，主要位于白髓周围的几层环状网状结构之间。猫的脾中没有一些物种存在的白髓和红髓之间的细网状网。至边缘带的动脉毛细血管稀少。一些是白髓毛细血管的延续，另一些是红髓毛细血管的延续，可能是动脉周围巨噬细胞鞘(PAMS)轴向毛细血管的延续(椭圆体)。沉积在边缘地带的血细胞可以通过每一层环状网状结构中的许多开口到达红髓。淋巴细胞似乎向白髓和远离白髓的边缘地带迁移。位于边缘带周围网状结构的巨噬细胞吞噬细胞，但不摄取Thorotrast，尽管它包覆在细胞表面。由于动脉末端的稀少和缺乏巨噬细胞带电的网状网，猫脾的边缘区域不是血液清除和吞噬的主要部位。这些功能在PAMS和红浆中发挥得更好。
The marginal zone in the cat spleen consisted of a characteristic mixture of lymphocytes and other blood cells located mainly between the several layers of circumferential reticulum around white pulp. A region of fine-meshed reticulum between white pulp and red pulp, as present in some species, was absent from the cat spleen. Arterial capillaries to the marginal zone were few. Some were continuations of white pulp capillaries; others were red pulp capillaries that probably were continuations of axial capillaries of periarterial macrophage sheaths (PAMS) (ellipsoids). Blood cells deposited in the marginal zone could reach red pulp by passing through the numerous openings in each layer of circumferential reticulum. Lymphocytes appeared to migrate across the marginal zone both toward and away from white pulp. Macrophages lying on the circumferential reticulum of the marginal zone phagocytized cells but did not ingest Thorotrast, although it coated their surfaces. Because of the scarcity of arterial endings and the lack of a macrophage-charged reticular meshwork, the marginal zone in cat spleen is not a major site of blood clearance and phagocytosis. These functions are better served in PAMS and red pulp.