Acid-promoted rapid solvent-free access to substituted 1,4-dihydropyridines from bketothioamides
Acid-promoted rapid solvent-free access to substituted 1,4-dihydropyridines from bketothioamides
复制标题
酸促进从硫代酮酰胺中快速无溶剂合成取代的 1,4-二氢吡啶
DOI：
10.1039/c5ra26931h
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发表时间：
2016
期刊：
影响因子：
3.9
通讯作者：
Li-Rong Wen
中科院分区：
文献类型：
--
作者：
Ming Li;Ke-Na Sun;Li-Rong Wen
在无溶剂条件下，以β-酮硫酰胺（KTAs）与醛和β-胺腈为原料，在AcOH存在下，在5min内合成1,4-二氢吡啶。该方法具有化学选择性高、反应条件温和、底物易得、产率高等特点。
β-Ketothioamides (KTAs) have been used as building blocks with aldehydes and β-enaminonitriles for synthesis of 1,4-dihydropyridines in the presence of AcOH under solvent-free conditions within 5 min. This new strategy exhibits remarkable features such as high chemoselectivity, mild reaction conditions, easily available substrates, and good yields.