Association of Mycoplasma genitalium and HIV infection: a systematic review and meta-analysis
Association of Mycoplasma genitalium and HIV infection: a systematic review and meta-analysis
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DOI：
10.1097/qad.0b013e328323da3e
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发表时间：
2009-03-13
期刊：
影响因子：
3.8
通讯作者：
Weiss, Helen Anne
中科院分区：
文献类型：
--
作者：
Mavedzenge, Sue Napierala;Weiss, Helen Anne
目的：系统回顾生殖支原体及其与成人 HIV 感染之间关系的研究，并总结荟萃分析的结果。设计：系统回顾和荟萃分析。方法：通过对已发表文献的系统回顾，确定了 2008 年 6 月之前发表的生殖支原体与 HIV 感染关系的流行病学研究。使用随机效应荟萃分析来计算总结比值比 (OR) 和 95% 置信区间 (0)。根据地理区域和对照人群类型进行进一步分析，并进行敏感性分析以评估研究间异质性和发表偏倚。结果：确定了 19 项合格研究。生殖支原体的患病率为3.19%至47.5%。十七项研究发现，患有生殖支原体的参与者更有可能感染艾滋病毒，并且这种关联在 12 项研究中具有统计学意义。总比值比 (OR) 为 2.01 [95% 置信区间 (CI) = 1.44-2.79]。在撒哈拉以南非洲的研究（OR-2.60，95% CI=2.17-3.11）和健康对照人群的研究（OR=2.57，95% CI=2.05-3.22）的亚组分析中，这种相关性更强。有强有力的证据表明所有研究之间存在研究间异质性；然而，亚组分析中研究间的异质性大大降低。没有发表偏倚的统计证据。结论：在这些主要是横断面观察性研究中，生殖支原体与 HIV 感染之间的密切关联凸显了纵向研究的必要性，以了解这些感染之间的时间关联。应将高危人群中生殖支原体阳性个体的检测和治疗作为潜在的艾滋病毒预防策略进行研究。 (c) 2009 年威科健康 |利平科特·威廉姆斯·威尔金斯
Objective: To systematically review studies of Mycoplasma genitalium and the association with HIV infection in adults and to summarize the findings in a meta-analysis.Design: A systematic review and meta-analysis.Methods: Epidemiological studies of the association of M. genitalium and HIV infection published prior to June 2008 were identified in a systematic review of the published literature. A random-effects meta-analysis was used to calculate the summary odds ratio (OR) and 95% confidence interval (0). Further analyses stratified by geographical area and type of control population, and sensitivity analyses were conducted to assess between-study heterogeneity and publication bias.Results: Nineteen eligible studies were identified. The prevalence of M. genitalium ranged from 3.19% to 47.5%. Seventeen studies found that participants with M. genitalium were more likely to be HIV infected, and this association was statistically significant in 12 studies. The summary odds ratio (OR) was 2.01 [95% confidence interval (CI) = 1.44-2.79]. The association was stronger in sub-group analyses among studies in sub-Saharan Africa (OR-2.60, 95% CI=2.17-3.11) and studies with healthy control populations (OR=2.57, 95% CI=2.05-3.22). There was strong evidence of between-study heterogeneity among all studies combined; however, between-study heterogeneity was substantially reduced in sub-group analyses. There was no statistical evidence of publication bias.Conclusion: The strong association between M. genitalium and HIV infections in these primarily cross-sectional observational studies highlights the need for longitudinal studies to understand the temporal association between these infections. Testing and treatment of M. genitalium-positive individuals in high-risk populations should be investigated as a potential HIV prevention strategy. (c) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins