Galantamine, an acetylcholinesterase inhibitor, reduces brain damage induced by hypoxia-ischemia in newborn rats
Galantamine, an acetylcholinesterase inhibitor, reduces brain damage induced by hypoxia-ischemia in newborn rats
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DOI：
10.1016/j.ijdevneu.2014.06.011
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发表时间：
2014-10-01
影响因子：
1.8
通讯作者：
Sameshima, Hiroshi
中科院分区：
文献类型：
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作者：
Furukawa, Seishi;Yang, Li;Sameshima, Hiroshi
目的：我们的目的是阐明加兰他敏（一种乙酰胆碱酯酶抑制剂）是否可以减少缺氧缺血 (HI) 引起的脑损伤。研究设计：使用 7 日龄的 Wistar 大鼠。对大鼠进行左颈动脉结扎，然后缺氧2小时（8%氧气）。我们在缺氧前（5.0 mg/kg，n=14；2.5 mg/kg，n=9；1.0 mg/kg，n=11）和缺氧后（5.0 mg/kg，n=7）腹腔注射加兰他敏，以确定其神经保护作用。在低氧负荷之前（n=31）和之后（n=7）施用等体积的盐水作为对照。我们还检查了注射加兰他敏（缺氧前；5.0 mg/kg，n=7）或盐水（n=8）后结扎半球侧IL-1β的产生。 HI后7天对大脑进行分析。结果：5.0mg/kg加兰他敏预处理的大鼠中的两只和后处理的大鼠在实验期间死亡。其余的存活者和 5.0 mg/kg 加兰他敏预处理的大鼠表现出脑损伤显着减少 (p
Aim: Our aim is to elucidate whether galantamine, known as an acetylcholinesterase inhibitor, reduces brain damage induced by hypoxia-ischemia (HI).Study design: 7-day-old Wistar rats were used. Rats were subjected to left carotid artery ligation followed by 2 h of hypoxia (8% oxygen). We injected galantamine intraperitoneally just before hypoxia (5.0 mg/kg, n=14; 2.5 mg/kg, n=9; 1.0 mg/kg, n=11) and after hypoxia (5.0 mg/kg, n=7) to determine its neuroprotective effect. An equivalent volume of saline was administered as a control before (n=31) and after hypoxic load (n=7). We also examined the production of IL-1 beta in the ligated hemisphere side after injection of galantamine (prior hypoxia; 5.0 mg/kg, n=7) or saline (n=8). Brains were analyzed 7 days after HI.Results: Two of the 5.0 mg/kg galantamine pre-treated rats and a post-treated rat died during experiments. The remaining survived and 5.0 mg/kg galantamine pre-treated rats showed a marked reduction of brain damage (p