Cisplatin: polymorphism and structural insights into an important chemotherapeutic drug.

Cisplatin: polymorphism and structural insights into an important chemotherapeutic drug.
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DOI:
10.1002/anie.201003185
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发表时间:
2010-12
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通讯作者:
V. Ting;M. Schmidtmann;Chick C. Wilson;M. Weller
V. Ting;M. Schmidtmann;Chick C. Wilson;M. Weller
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文献类型:
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作者:
V. Ting;M. Schmidtmann;Chick C. Wilson;M. Weller

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The changing face of cisplatin: The complete crystal structures, including the details of extensive intermolecular hydrogen bonding in two enantiotropic polymorphs of the chemotherapeutic drug cisplatin, have been elucidated. A massive thermal hysteresis effect exists between the two polymorphs, α and β, that are active at ambient temperatures.