Self-assembled multivalent carbohydrate ligands.
Self-assembled multivalent carbohydrate ligands.
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DOI：
10.1039/b615744k
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发表时间：
2007-01
影响因子：
3.2
通讯作者：
Y. Lim;Myongsoo Lee
中科院分区：
文献类型：
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作者：
Y. Lim;Myongsoo Lee
显示多个碳水化合物残基的材料由于其抑制或调节生物多价相互作用的潜力而受到广泛关注。这些材料可以根据它们的制备方式进行分组，作为单分子或自组装系统。两种系统都利用了多价相互作用具有比相应的单价相互作用显著更高的结合亲和力的事实。与单分子系统相比，自组装系统是一个更新的研究领域。在这篇综述中，我们描述了目前的努力，实现多价糖相互作用的角度来看，合成自组装系统。我们的范围限制自组装系统是稳定的，可溶于水溶液和形态离散。我们把他们分成两类。在第一类中，碳水化合物配体自组装到预组织的纳米结构上，并且在第二类中，碳水化合物缀合的嵌段分子自发地组装以构建形态上不同的纳米结构。
Materials that display multiple carbohydrate residues have gained much attention due to their potential to inhibit or modulate biological multivalent interactions. These materials can be grouped accordingly to the way they are prepared, as unimolecular or as self-assembled systems. Both systems take advantage of the fact that multivalent interactions have significantly higher binding affinity than the corresponding monovalent interactions. The self-assembled system is a more recent field of research compared to the unimolecular system. In this review, we describe current efforts to realize multivalent carbohydrate interactions from the perspective of synthetic self-assembled systems. We limit the scope to self-assembled systems that are stable, soluble in aqueous solution and morphologically discrete. We grouped them into two separate categories. In the first category carbohydrate ligands self-assemble onto a pre-organized nanostructure, and in the second carbohydrate-conjugated block molecules spontaneously assemble to construct morphologically distinct nanostructures.