Low Serum Superoxide Dismutase Is Associated With a High Risk of Cognitive Impairment After Mild Acute Ischemic Stroke.
Low Serum Superoxide Dismutase Is Associated With a High Risk of Cognitive Impairment After Mild Acute Ischemic Stroke.
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低血清超氧化物歧化酶与轻度急性缺血性中风后认知障碍的高风险相关
DOI：
10.3389/fnagi.2022.834114
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发表时间：
2022
影响因子：
4.8
通讯作者：
Yin J
中科院分区：
文献类型：
--
作者：
Zhang MS;Liang JH;Yang MJ;Ren YR;Cheng DH;Wu QH;He Y;Yin J
脑卒中后认知障碍（PSCI）是脑卒中后常见的并发症，但有效的治疗方法有限。识别潜在的危险因素以进行有效的干预是必要的。我们通过前瞻性队列设计研究了血清超氧化物歧化酶（SOD）水平是否与轻度急性缺血性卒中（AIS）后的认知功能障碍有关。共招募187例诊断为轻度AIS（美国国立卫生研究院卒中量表≤8）的患者。测定血清超氧化物歧化酶（SOD）、红细胞沉降率（ESR）、c反应蛋白（CRP）和白细胞介素6 （IL-6）水平，并在早期（2周内）进行认知评估（MMSE, Mini-Mental State Examination; MoCA, Montreal cognitive Assessment）。在发病后3个月重复这些指标和评估。MoCA < 22定义为脑卒中后2周内的早期认知障碍（CI-E）和3个月后的晚期认知障碍（CI-L）。在一项调查中，187例患者中有105例（56.1%）在轻度AIS后被诊断为CI-E。在CI-E患者中观察到较低的血清SOD与较高的炎症生物标志物（ESR、CRP和IL-6）和较差的认知评分相关。在一项调查中，103例完成3个月随访的卒中患者中有39例（37.9%）被确定为CI-L。CI-L患者在基线和3个月时血清SOD持续降低，并与认知评分呈正相关。在校正分析中，基线时低血清SOD与CI-E和CI-L的高风险独立相关，比值比（or）分别为0.64和0.33。多调整样条回归模型显示血清SOD与CI-E（线性关系P = 0.044）和CI-L（线性关系P = 0.006）呈线性相关。在3个月的随访中，35.2%（19/54）的CI-E患者认知功能恢复。在多变量分析中，SOD被确定为脑卒中后认知恢复的保护因素（OR 1.04, 95% CI: 1.01-1.08, P = 0.024）。我们证明低血清SOD与轻度AIS后认知功能障碍的高风险相关，表明SOD可能是PSCI的潜在可改变因素。
Post-stroke cognitive impairment (PSCI) is a common complication after stroke, but effective therapy is limited. Identifying potential risk factors for effective intervention is warranted. We investigated whether serum superoxide dismutase (SOD) levels were related to cognitive impairment after mild acute ischemic stroke (AIS) by using a prospective cohort design. A total of 187 patients diagnosed with mild AIS (National Institutes of Health Stroke Scale ≤ 8) were recruited. Serum SOD, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and interleukin-6 (IL-6) levels were measured, and cognitive assessments (Mini-Mental State Examination, MMSE; Montreal Cognitive Assessment, MoCA) were performed in the early phase (within 2 weeks). These indexes and assessments were repeated at 3 months after onset. MoCA < 22 was defined as early cognitive impairment (CI-E) within 2 weeks and late cognitive impairment (CI-L) at 3 months after stroke. In a survey, 105 of 187 (56.1%) patients were identified as CI-E after mild AIS. Lower serum SOD associated with higher inflammatory biomarkers (ESR, CRP, and IL-6) and worse cognitive scores was observed in CI-E patients. In a survey, 39 of 103 (37.9%) stroke patients who completed the 3-month follow-up were identified as CI-L. Serum SOD was consistently lower in CI-L patients at baseline and 3 months and positively associated with cognitive scores. In adjusted analyses, low serum SOD at baseline was independently associated with high risks of CI-E and CI-L, with odds ratios (ORs) of 0.64 and 0.33 per standard deviation increase in serum SOD, respectively. Multiple-adjusted spline regression models showed linear associations between serum SOD and CI-E (P = 0.044 for linearity) and CI-L (P = 0.006 for linearity). Moreover, 35.2% (19/54) of CI-E patients cognitively recovered during the 3-month follow-up. In multivariable analysis, SOD was identified as a protective factor for cognitive recovery after stroke (OR 1.04, 95% CI: 1.01–1.08, P = 0.024). We demonstrate that low serum SOD is associated with a high risk of cognitive impairment after mild AIS, indicating SOD may be a potential modifiable factor for PSCI.
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DOI：
10.1523/jneurosci.0295-20.2020
发表时间：
2021-01-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fracassi A;Marcatti M;Zolochevska O;Tabor N;Woltjer R;Moreno S;Taglialatela G
通讯作者：
Taglialatela G
影响因子：
4.2
作者：
Lee WH;Kumar A;Rani A;Foster TC
通讯作者：
Foster TC
影响因子：
8.3
作者：
Shin, Minyoung;Sohn, Min Kyun;Kim, Yun-Hee
通讯作者：
Kim, Yun-Hee
影响因子：
8.3
作者：
Sagnier, Sharmila;Okubo, Gosuke;Sibon, Igor
通讯作者：
Sibon, Igor
超氧化物歧化酶模拟tempol的神经保护特性与在啮齿动物模型中减少病理谷氨酸释放的能力相关。
影响因子：
7.4
作者：
Dohare, Preeti;Hyzinski-Garcia, Maria C.;Vipani, Aarshi;Bowens, Nicole H.;Nalwalk, Julia W.;Feustel, Paul J.;Keller, Richard W., Jr.;Jourd'heuil, David;Mongin, Alexander A.
通讯作者：
Mongin, Alexander A.