Nine months in space: effects on human autonomic cardiovascular regulation.
Nine months in space: effects on human autonomic cardiovascular regulation.
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DOI：
10.1152/jappl.2000.89.3.1039
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发表时间：
2000-09
影响因子：
3.3
通讯作者：
William H. Cooke;J. E. Ames;Alexandra A. Crossman;J. Cox;Tom A. Kuusela;Kari U. O. Tahvanainen;L. Boyce Moon;Jürgen Drescher;F. Baisch;Tadaaki Mano;Benjamin D. Levine;C. Blomqvist;D. Eckberg
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文献类型：
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作者：
William H. Cooke;J. E. Ames;Alexandra A. Crossman;J. Cox;Tom A. Kuusela;Kari U. O. Tahvanainen;L. Boyce Moon;Jürgen Drescher;F. Baisch;Tadaaki Mano;Benjamin D. Levine;C. Blomqvist;D. Eckberg
我们研究了三名俄罗斯宇航员，以更好地了解长期暴露在微重力下如何影响自主心血管控制。我们记录了心电图，手指光电体积描记压力，呼吸流量之前，期间和之后的两个9个月的任务，俄罗斯和平号空间站。在四种呼吸模式下进行测量：1）不受控制的自主呼吸; 2）六种不同频率的逐步呼吸; 3）固定频率呼吸; 4）随机频率呼吸。在太空中，两名宇航员的R波到R波（R-R）间期标准差降低，呼吸频率R-R间期谱功率降低。宇航员返回地球两周后，R-R间期频谱功率降低，收缩压频谱功率增加。收缩压和R-R间期之间的传递函数在飞行中降低，在着陆后第二天进一步降低，并且在着陆后14天没有恢复到飞行前的水平。我们的研究结果表明，长时间的太空飞行减少了迷走神经-心脏神经的交通，减少了迷走神经压力反射的增益，这些变化可能会持续长达2周后返回地球。
We studied three Russian cosmonauts to better understand how long-term exposure to microgravity affects autonomic cardiovascular control. We recorded the electrocardiogram, finger photoplethysmographic pressure, and respiratory flow before, during, and after two 9-mo missions to the Russian space station Mir. Measurements were made during four modes of breathing: 1) uncontrolled spontaneous breathing; 2) stepwise breathing at six different frequencies; 3) fixed-frequency breathing; and 4) random-frequency breathing. R wave-to-R wave (R-R) interval standard deviations decreased in all and respiratory frequency R-R interval spectral power decreased in two cosmonauts in space. Two weeks after the cosmonauts returned to Earth, R-R interval spectral power was decreased, and systolic pressure spectral power was increased in all. The transfer function between systolic pressures and R-R intervals was reduced in-flight, was reduced further the day after landing, and had not returned to preflight levels by 14 days after landing. Our results suggest that long-duration spaceflight reduces vagal-cardiac nerve traffic and decreases vagal baroreflex gain and that these changes may persist as long as 2 wk after return to Earth.