Distribution of enterovirus genotypes detected in clinical samples in Hungary, 2010-2018
Distribution of enterovirus genotypes detected in clinical samples in Hungary, 2010-2018
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DOI：
10.1556/030.2020.01200
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发表时间：
2020-12-01
影响因子：
1.5
通讯作者：
Takacs, Maria
中科院分区：
文献类型：
--
作者：
Bujaki, Erika;Farkas, Agnes;Takacs, Maria
本报告提供了一项回顾性监测研究的结果，该研究对2010- 2018年期间在匈牙利国家肠道病毒参考实验室检测到的9年期间肠道病毒及其相关临床症状的出现和传播进行了回顾性监测。从4,080份临床标本中确定了25种EV类型，患者的中位年龄为5岁，68%的病例累及10岁或10岁以下的儿童，尽管感染发生在所有年龄组。130例有神经系统症状，123例有皮肤感染，包括手足口病、疱疹性咽峡炎和皮疹。在2010年，EV-A71被发现导致大多数诊断的EV感染，而在2011年和2014年至2018年，柯萨奇病毒（CV）-A6被最常发现。2012年埃可病毒E6占大多数病例，2013年埃可病毒30占主导地位。EV-D 68仅在2010年和2013年被发现，目前流行的EV-A和EV-B病毒较多，EV-C和EV-D病毒偶有发生。EV在散发病例和定期爆发中引起严重感染的能力突出了继续监测流行EV类型的重要性。
This report provides the findings of a retrospective surveillance study on the emergence and circulation of enteroviruses with their associated clinical symptoms over a nine-year period detected at the National Enterovirus Reference Laboratory in Hungary between 2010-2018.Enterovirus (EV) detection and genotyping were performed directly from clinical samples. From 4,080 clinical specimens 25 EV types were identified with a median age of patients of 5 years and 68% of all cases affected children aged 10 years or younger, although infections occurred in all age-groups. In 130 cases neurological symptoms were recorded, in 123 cases the infection presented in skin related signs including hand, foot, and mouth disease (HFMD), herpangina and rash. In 2010 EV-A71 was found to cause the majority of diagnosed EV infections while in 2011 and from 2014 2018, Coxsackievirus (CV)-A6 was identified most often. Echovirus E6 accounted for the most cases in 2012 and Echovirus 30 dominated in 2013. EV-D68 was identified only in 2010 and 2013.Widespread circulation of several EV-A and EV-B viruses with occasional occurrence of EV-C and EV-D was detected. The ability of EVs to cause severe infections in sporadic cases and regular outbreaks highlight the importance of continued monitoring of circulating EV types.