Effects of type of smoking (pipe, cigars or cigarettes) on biological indices of tobacco exposure and toxicity
Effects of type of smoking (pipe, cigars or cigarettes) on biological indices of tobacco exposure and toxicity
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DOI：
10.1016/j.lungcan.2006.06.016
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发表时间：
2006-10-01
期刊：
影响因子：
5.3
通讯作者：
Roussel, Ronan
中科院分区：
文献类型：
--
作者：
Funck-Brentano, Christian;Raphael, Mathilde;Roussel, Ronan
虽然所有形式的吸烟都是有害的，但与吸烟相比，吸烟烟斗或雪茄与较低的烟草制品致命产品暴露以及较低的发病率和死亡率水平有关。细胞色素P-450-1A（CYP 1A）是激活烟草烟雾中致癌物质的主要途径。我们的主要目的是比较只吸烟斗或雪茄的人，只吸烟的人和不吸烟的人的CYP 1A 2活性。我们研究了30只烟斗或雪茄的吸烟者，28只香烟的吸烟者和30名年龄匹配的非吸烟者。CYP 1A 2活性以血浆中咖啡因代谢率评估。一天的尿液收集用于确定暴露于烟草代谢产物。亚硝胺和苯并[a]芘DNA加合物在淋巴细胞中进行了测量。CYP 1A 2活性更高（p
Although all forms of smoking are harmful, smoking pipes or cigars is associated with lower exposure to the lethal products of tobacco products and lower Levels of morbidity and mortality than smoking cigarettes. Cytochrome P-450-1A (CYP1A) is a major pathway activating carcinogens from tobacco smoke. Our primary aim was to compare CYP1A2 activity in individuals smoking pipes or cigars only, cigarettes only and in non-smokers. We studied 30 smokers of pipes or cigars only, 28 smokers of cigarettes only, and 30 non-smokers mate subjects matched for age. CYP1A2 activity was assessed as the caffeine metabolic ratio in plasma. One-day urine collection was used for determining exposure to products of tobacco metabotism. Nitrosamine and benzo[a]pyrene DNA adducts were measured in lymphocytes. CYP1A2 activity was greater (p