NEUROMUSCULAR-JUNCTIONS AND ALPHA-BUNGAROTOXIN-BINDING SITES IN DENERVATED AND CONTRALATERAL CAT SKELETAL-MUSCLES
NEUROMUSCULAR-JUNCTIONS AND ALPHA-BUNGAROTOXIN-BINDING SITES IN DENERVATED AND CONTRALATERAL CAT SKELETAL-MUSCLES
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DOI：
10.1113/jphysiol.1981.sp013679
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发表时间：
1981-01-01
影响因子：
5.5
通讯作者：
STEINBACH, JH
中科院分区：
文献类型：
--
作者：
STEINBACH, JH
研究了正常猫和去神经猫后肢快肌骨骼肌以及去神经肌肉对侧肌肉中胆碱酯酶（ChE）活性和乙酰胆碱（ACh）受体的分布。在正常的肌纤维上，几乎所有受体都局限于紧邻连接后的膜，尽管在快肌纤维和慢肌纤维上都发现了ACh受体密度增加的连接周围梯度。去神经支配后，结外ACh受体密度大大增加，并在至少10个月内保持较高水平。去神经支配的肌肉中出现了 ChE 活性染色和具有高密度 ACh 受体的异位区域。去神经后连接ACh受体的数量缓慢减少，半衰期约为140天。与去神经肌肉对侧的快肌也显示出变化，包括交界尺寸的增加以及交界外乙酰胆碱受体密度的小幅但显着的增加。
The distributions of cholinesterase (ChE) activity and acetylcholine (ACh) receptors were studied in normal and denervated cat hind-limb fast-twitch skeletal muscles and in muscles contralateral to denervated muscles. On normal muscle fibers almost all receptors were confined to the immediately post-junctional membrane, although a perijunctional gradient of increased ACh receptor density was found on both fast- and slow-twitch fibers. After denervation, the extrajunctional ACh receptor density increased greatly and remained high for at least 10 mo. Ectopic regions staining for ChE activity and having a high density of ACh receptors appeared in denervated muscle. The number of junctional ACh receptors decreased slowly after denervation, with a half-time of about 140 days. Fast-twitch muscles contralateral to denervated muscles also showed changes, including an increase in junctional size and a small but significant increase in extrajunctional ACh receptor density.