Impacts of Preeclampsia on the Brain of the Offspring
Impacts of Preeclampsia on the Brain of the Offspring
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DOI：
10.1055/s-0036-1584515
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发表时间：
2016-08-01
期刊：
影响因子：
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通讯作者：
Figueiró-Filho, Ernesto A.
中科院分区：
文献类型：
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作者：
Dang, Frances;Croy, B. Anne;Figueiró-Filho, Ernesto A.
子痫前期(PE)是一种严重的妊娠障碍，在所有人类妊娠中会导致35%的并发症。除了对母亲和胎儿的直接风险和并发症外，这两种疾病都会增加特定并发症的终身风险。PE妊娠的后代(PE-F1)患高血压、中风和认知障碍的风险比匹配良好的复杂妊娠的后代(F1)更高。在临床发生PE之前，胎盘血管因子分泌到母体血浆中是有偏差的。在许多PE患者中，这包括胎盘生长因子(PGF)的缺陷。我们的实验室发现，PGF基因缺失的小鼠(PGF-/-)改变了从怀孕中期到成年的脑血管和脑神经发育。我们假设，在人类PE中看到的PGF缺陷，以一种损害认知功能和增加中风风险的方式偏离了胎儿脑血管和神经发育。在这里，我们总结了对8-10岁的男性和女性的PE-F1和匹配的对照的初步研究的初步分析结果。本研究首次报道了PE-F1的磁共振成像(MRI)、磁共振血管成像(MRA)以及眼动控制和临床心理测验对脑区功能的评估。在更大的队列中进行进一步的研究对于确定是否存在基于图像的生物标记物来描述PE-F1大脑的独特解剖特征是至关重要的。
Preeclampsia (PE) is a significant gestational disorder that causes complications in 35% of all human pregnancies. Apart from the immediate risks and complications for mother and fetus, both additionally carry elevated lifelong risks for specific complications. Offspring of PE pregnancies (PE-F1) have higher risks for hypertension, stroke and cognitive impairment compared with well-matched offspring (F1) fromuncomplicated pregnancies. Prior to the clinical onset of PE, placental angiokines secreted into the maternal plasma are deviated. In many PE patients this includes deficits in placental growth factor (PGF). Our laboratory found that mice genetically-deleted for PGF (PGF -/-) have altered cerebrovascular and brain neurological development detectable from midgestation to adulthood. We hypothesized that the PGF deficits seen in human PE, deviate fetal cerebrovascular and neurological development in a manner that impairs cognitive functions and elevates stroke risk. Here we summarize the initial analytical outcomes from a pilot study of 8-10 year old male and female PE-F1s and matched controls. Our studies were the first to report magnetic resonance imaging (MRI), magnetic resonance angiography (MRA) and functional brain region assessment by eyemovement control and clinical psychometric testing in PE-F1s. Further studies in larger cohorts are essential to define whether there are image-based biomarkers that describe unique anatomical features in PE-F1 brains.