CD11b Expression on circulating leukocytes increases in preparation for parturition.
CD11b Expression on circulating leukocytes increases in preparation for parturition.
复制标题
循环白细胞上的 CD11b 表达增加，为分娩做准备。
DOI：
10.1111/j.1600-0897.2004.00229.x
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Deloia,JulieA
中科院分区：
文献类型：
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作者：
Luppi,Patrizia;Irwin,TracyE;Simhan,Hyagriv;Deloia,JulieA
问题：分娩的开始与白细胞向生殖道迁移有关。这种迁移在一定程度上受白细胞和血管内皮细胞表面黏附分子表达的控制。在生殖道内，某些内皮细胞黏附分子，包括细胞间黏附分子-1(ICAM-1)，在妊娠结束时上调。ICAM-1与白细胞表面的β-2整合素CD11b结合。本研究旨在探讨孕妇外周血白细胞表面黏附分子表达在备产过程中是否发生了互补性变化。研究方法：采用流式细胞术检测妊娠晚期及分娩过程中外周血白细胞黏附分子表达的变化。结果：妊娠37 时孕妇外周血中单核细胞及粒细胞表面CD11b的表达显著增加。结论：CD11b可能是妊娠末期白细胞向生殖道转运的关键分子。
Problem:Initiation of parturition is associated with migration of leukocytes to the reproductive tract. This migration is controlled in part by expression of adhesion molecules on the surface of leukocytes and vascular endothelial cells. Within the reproductive tract, certain endothelial adhesion molecules, including intercellular adhesion molecule‐1 (ICAM‐1), are up‐regulated at the end of gestation. ICAM‐1 binds to theβ2integrin CD11b on the leukocytes. In this study, we wanted to investigate whether complementary changes occur in expression of adhesion molecules on maternal leukocytes in preparation for parturition.Method of study:We used flow cytometry to ascertain changes in adhesion molecules expression on leukocytes throughout third trimester and labor.Results:We found a significant increase in the expression of CD11b on monocytes and granulocytes in women at >37 weeks of gestation.Conclusions:CD11b may be a key molecule for leukocyte trafficking to the reproductive tract at the end of pregnancy.