Stereoselective syntheses of (±)-komaroviquinone and (±)-faveline methyl ether through intramolecular Heck reaction
Stereoselective syntheses of (±)-komaroviquinone and (±)-faveline methyl ether through intramolecular Heck reaction
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DOI：
10.1021/jo051082i
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发表时间：
2005-09-16
影响因子：
3.6
通讯作者：
Banerjee, AK
中科院分区：
文献类型：
--
作者：
Sengupta, S;Drew, MGB;Banerjee, AK
通过分子内Heck反应，实现了一条高效、灵活、立体选择性的合成反式-10-羟基-1，1-二甲基八氢二苯并[a，d]环庚烯-7-酮（5a-c）的聚合路线.该策略已成功地用于通过（+/-）-库尔特酮二甲醚（5c）和（+/-）-凡士林甲醚（1a）合成（+/-）-科马罗维醌（3）。
An efficient, flexible, and stereoselective convergent route for constructing the trans-10-hydroxy1,1-dimethyloctahydrodibenzo[a,d]cyclohepten-7-ones (5a-c) was achieved via intramolecular Heck reaction. This strategy has been successfully implemented for the syntheses of (+/-)-komaroviquinone (3) through (+/-)-coulterone dimethyl ether (5c) and (+/-)-faveline methyl ether (1a).