Interactive effects of O3, cytochalasin D, and vinblastine on transepithelial transport and cytoskeleton in rat airways.
Interactive effects of O3, cytochalasin D, and vinblastine on transepithelial transport and cytoskeleton in rat airways.
复制标题
O3、细胞松弛素 D 和长春花碱对大鼠气道跨上皮转运和细胞骨架的相互作用。
DOI：
10.1165/ajrcmb/3.2.119
复制
发表时间：
1990
影响因子：
6.4
通讯作者：
Tjen,S
中科院分区：
文献类型：
--
作者：
Bhalla,DK;Rasmussen,RE;Tjen,S
In cultured cells, permeability can be altered by treatment with cytoskeleton disrupting agents or chemically generated toxic oxygen metabolites. In epithelial cells, which form tight junctions in culture, disruption of microfilaments by cytochalasin B resulted in opening of tight junctions and a decrease in electrical resistance (9). Cytochalasin B also fragmented microfilaments and increased permeability to albumin in endothelial cell monolayers (10). A similar disruption of actin filaments and a concomitant increase in perme-
