Circular RNAs in human cancer.
Circular RNAs in human cancer.
复制标题
人类癌症中的环状RNA
DOI：
10.1186/s12943-017-0598-7
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发表时间：
2017-01-31
期刊：
影响因子：
37.3
通讯作者：
Xiong W
中科院分区：
文献类型：
--
作者：
Wang Y;Mo Y;Gong Z;Yang X;Yang M;Zhang S;Xiong F;Xiang B;Zhou M;Liao Q;Zhang W;Li X;Li X;Li Y;Li G;Zeng Z;Xiong W
环状RNA（circRNAs）是一类新型RNA。随着新一代测序（NGS）技术，尤其是RNA测序（RNA-seq）技术的新发展，现已发现超过30,000种环状RNA。由于其独特的结构，它们比线性RNA更为稳定。环状RNA在癌症发生过程中发挥着重要作用。环状RNA的表达与患者的临床特征相关，并且在恶性表型的诸多方面，如细胞周期、细胞凋亡、血管生成、侵袭与转移（作为RNA海绵，与RNA结合蛋白结合）或翻译等方面，都起着至关重要的作用。因此，进一步研究环状RNA与肿瘤之间的相互作用机制具有重要意义。环状RNA作为分子标志物或潜在靶点的作用，将为肿瘤的早期诊断、疗效评估、预后预测乃至基因治疗等提供广阔的应用前景。
CircRNAs are a novel type of RNAs. With the newly developed technology of next-generation sequencing (NGS), especially RNA-seq technology, over 30,000 circRNAs have already been found. Owing to their unique structure, they are more stable than linear RNAs. CircRNAs play important roles in the carcinogenesis of cancer. The expression of circRNAs is correlated with patients’ clinical characteristics, and circRNAs play a vital role in many aspects of malignant phenotypes, including cell cycle, apoptosis, vascularization, and invasion; metastasis as a RNA sponge, binding to RBP; or translation. Therefore, it is meaningful to further study the mechanism of interactions between circRNAs and tumors. The role of circRNAs as molecular markers or potential targets will provide promising application perspectives, such as early tumor diagnosis, therapeutic evaluation, prognosis prediction, and even gene therapy for tumors.