Closing in on a mechanism for activation.

Closing in on a mechanism for activation.
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DOI:
10.7554/elife.04909
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发表时间:
2014-10-28
期刊:
影响因子:
7.7
通讯作者:
Miller WT
Miller WT
中科院分区:
生物学1区
文献类型:
--
作者:
Hubbard SR;Miller WT

文献摘要

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当胰岛素样生长因子-1(IGF 1)与其受体结合时,释放了一种物理约束,允许两个跨膜螺旋聚集在一起,以促进受体的激活。
When insulin-like growth factor-1 (IGF1) binds to its receptor, a physical constraint is released that allows the two transmembrane helices to come together to facilitate activation of the receptor.