EFFECT OF AGE ON THE FREQUENCY OF ACTIVE CAMPYLOBACTER-PYLORI INFECTION DIAGNOSED BY THE [C-13] UREA BREATH TEST IN NORMAL SUBJECTS AND PATIENTS WITH PEPTIC-ULCER DISEASE
EFFECT OF AGE ON THE FREQUENCY OF ACTIVE CAMPYLOBACTER-PYLORI INFECTION DIAGNOSED BY THE [C-13] UREA BREATH TEST IN NORMAL SUBJECTS AND PATIENTS WITH PEPTIC-ULCER DISEASE
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DOI：
10.1093/infdis/157.4.777
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发表时间：
1988-04-01
影响因子：
6.4
通讯作者：
BOUTTON, TW
中科院分区：
文献类型：
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作者：
GRAHAM, DY;KLEIN, PD;BOUTTON, TW
我们研究了来自北美（n = 53）或中华民国（n = 15）无胃肠道症状或溃疡病史的人群以及经内镜检查诊断为活动性或近期活动性十二指肠或胃溃疡的患者（n = 105）活动性幽门弯曲菌感染的频率。消化性溃疡患者 (88%) 的幽门螺杆菌感染频率显着高于正常组 (45%)（P < .001）。在没有胃肠道症状的受试者中，幽门螺杆菌感染频率与年龄相关的增加与已知的胃炎患病率与年龄相关的增加是平行的。无论年龄大小，十二指肠溃疡患者幽门螺杆菌感染率> 80%。幽门螺杆菌感染在中国人群（年龄20-39岁）中比在同年龄的北美人群中更为常见（60%对24%）。如果不知道相同年龄和种族背景的参考人群中幽门螺杆菌感染的患病率，则不应推断幽门螺杆菌与特定疾病的关联。
We studied the frequency of active Campylobacter pylori infection in persons from North America (n = 53) or the People''s Republic of China (n = 15) who had no gastrointestinal symptoms or a history of ulcer disease and in patients with active or recently active duodenal or gastric ulcers diagnosed by endoscopy (n = 105). C. pylori infection was significantly (P < .001) more frequent in patients with peptic ulcers (88%) than in the normal group (45%). An age-related increase in the frequency of C. pylori infection in subjects with no gastrointestinal symptoms paralleled the known age-related increase in prevalence of gastritis. The frequency of C. pylori infection in patients with duodenal ulcers was > 80%, irrespective of age. C. pylori infection was more common in the Chinese group (age, 20-39 y) than in the North American group of the same age (60% vs. 24%). Association of C. pylori with specific diseases should not be inferred without knowing the prevalence of C. pylori infection in reference populations of the same age and ethnic background.