Cerebral and local cerebral metabolism in the cat during slow wave and REM sleep
Cerebral and local cerebral metabolism in the cat during slow wave and REM sleep
复制标题
猫在慢波和快速眼动睡眠期间的大脑和局部大脑代谢
DOI：
10.1016/0006-8993(86)90728-6
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发表时间：
1986
期刊：
影响因子：
2.9
通讯作者：
B. Frost
中科院分区：
文献类型：
--
作者：
P. Ramm;B. Frost
[14 C]2-脱氧葡萄糖放射自显影用于显示猫慢波睡眠（SWS）和快眼动睡眠（REM）期间的脑和局部脑代谢。反映脑能量守恒的平均脑代谢水平较低，与SWS相关。没有观察到REM和平均脑代谢之间的明确联系。在区域水平上，SWS与丘脑感觉中继和皮层的代谢显著降低有关。REM与小脑中相对较低的代谢有关，但与海马体和包括三叉神经和红核在内的一些“运动”区域中相对较高的代谢有关。因此，SWS与大脑能量守恒有关，并且与皮质和皮质下感觉区域的功能活动水平特别低有关。快速眼动与慢波综合征的不同之处在于：（1）快速眼动似乎与大脑能量守恒没有密切联系;（B）与慢波综合征相比，快速眼动与代谢有关的脑区较少;（3）大多数与快速眼动有关的脑区表现出相对较高的代谢水平。此外，虽然慢波综合征与感觉区域的功能活动最明显相关，但快速眼动与少数边缘系统和运动区域的功能活动有关。总而言之，慢波睡眠和快速眼动与独特的大脑代谢和功能状态相关。
[14C]2-deoxyglucose autoradiography was used to show cerebral and regional cerebral metabolism during slow-wave sleep (SWS) and rapid-eye-movement sleep (REM) in the cat. Lower levels of mean cerebral metabolism, reflecting cerebral energy conservation, were associated with SWS. A clear link between REM and mean cerebral metabolism was not observed. At the regional level, SWS was associated with markedy low metabolism in thalamic sensory relays and in cortex. REM was associated with relatively low metabolism in the cerebellum, but with relatively high metabolism in the hippocampus, and in some ‘motor’ regions including the trigeminal and red nuclei. Thus, SWS was linked to cerebral energy conservation and to particularly low levels of functional activity in cortical and sub-cortical sensory regions. REM was unlike SWS in that: (a) REM did not appear to be strongly linked to cerebral energy conservation; (b) REM was linked to metabolism in fewer brain regions than was SWS; and (c) most REM-linked regions exhibited relatively high levels of metabolism. In addition, while SWS was most clearly associated with functional activity in sensory regions, REM was linked to functional activity in a small number of limbic and motor regions. In sum, SWS and REM are associated with distinctive cerebral metabolic and functional states.