An electrophysiological marker of arousal level in humans
An electrophysiological marker of arousal level in humans
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DOI：
10.7554/elife.55092
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发表时间：
2020-07-28
期刊：
影响因子：
7.7
通讯作者：
Knight, Robert T.
中科院分区：
文献类型：
--
作者：
Lendner, Janna D.;Helfrich, Randolph F.;Knight, Robert T.
深度非快速眼动睡眠（NREM）和丙泊酚全身麻醉是与脑电图（EEG）同步振荡发生相关的显著觉醒减少状态。虽然快速眼动（REM）睡眠也与唤醒水平降低有关，但它的特征是去兴奋化的“唤醒样”EEG。这一观察结果意味着减少的唤醒状态不一定仅由同步振荡活动定义。使用颅内和表面脑电图记录在四个独立的数据集，我们表明，1/f频谱斜率的电生理功率谱，反映了非振荡，无标度的神经活动的组成部分，描绘清醒异丙酚麻醉，NREM和REM睡眠。重要的是，光谱斜率仅基于神经生理学大脑状态来区分觉醒和REM睡眠。总的来说，我们的研究结果描述了一种常见的电生理标志物，它可以跟踪唤醒减少的状态，包括人类的不同睡眠阶段以及麻醉。
Deep non-rapid eye movement sleep (NREM) and general anesthesia with propofol are prominent states of reduced arousal linked to the occurrence of synchronized oscillations in the electroencephalogram (EEG). Although rapid eye movement (REM) sleep is also associated with diminished arousal levels, it is characterized by a desynchronized, 'wake-like' EEG. This observation implies that reduced arousal states are not necessarily only defined by synchronous oscillatory activity. Using intracranial and surface EEG recordings in four independent data sets, we demonstrate that the 1/f spectral slope of the electrophysiological power spectrum, which reflects the non-oscillatory, scale-free component of neural activity, delineates wakefulness from propofol anesthesia, NREM and REM sleep. Critically, the spectral slope discriminates wakefulness from REM sleep solely based on the neurophysiological brain state. Taken together, our findings describe a common electrophysiological marker that tracks states of reduced arousal, including different sleep stages as well as anesthesia in humans.