PYY-preferring receptor in the dorsal vagal complex and its involvement in PYY stimulation of gastric acid secretion in rats.
PYY-preferring receptor in the dorsal vagal complex and its involvement in PYY stimulation of gastric acid secretion in rats.
复制标题
背侧迷走神经复合体中的 PYY 偏好受体及其参与 PYY 刺激大鼠胃酸分泌的过程。
DOI：
10.1038/sj.bjp.0701767
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发表时间：
1998
影响因子：
7.3
通讯作者：
Taché,Y
中科院分区：
文献类型：
--
作者：
Yang,H;Li,WP;ReeveJr,JR;Rivier,J;Taché,Y
微注射肽YY （PYY, 7-46 pmol）到背迷走神经复合体（DVC）刺激了氨基甲酸乙酯麻醉大鼠的胃酸分泌。利用多种神经肽Y （NPY）和PYY衍生物，我们表征了介导PYY酸分泌反应的受体的药理学特征。[Pro34]大鼠(r)/猪(p)PYY和[Pro34]人(h)PYY （23-117 pmol）单侧微注射于DVC后，净酸分泌最大增幅相似，分别达到68±11 μmol和89±31 μmol 90 min−1。大鼠/hNPY和pNPY （47 μmol）微注射于DVC后，净胃酸分泌量相近（分别为27±8 μmol和23±8 μmol， 90 min−1），较高剂量（116 μmol）有降低反应的趋势。胰多肽（PP, 4-46 pmol）， [Leu31,Pro34]r/hNPY（47和117 pmol）和Y2选择性激动剂hPYY3‐36，pNPY5‐36和pNPY13‐36（25-168 pmol）微注射到DVC中，对基础胃酸分泌没有影响。PYY[Pro34]r/pPYY=[Pro34]hPYY>r/hNPY=pNPY注射到DVC后刺激胃酸分泌的效序和PP、[Leu31，Pro34]NPY和C端NPY/PYY片段的无效提示可能有PYY偏好受体亚型参与了刺激作用的介导。英国药理学杂志（1998）123,1549-1554；doi: 10.1038 / sj.bjp.0701767
Microinjection of peptide YY (PYY, 7–46 pmol) into the dorsal vagal complex (DVC) stimulated gastric acid secretion in urethane‐anaesthetized rats. Using a variety of neuropeptide Y (NPY) and PYY derivatives, we characterized the pharmacological profile of the receptor mediating the acid secretory response to PYY.[Pro34]rat(r)/porcine(p)PYY and [Pro34]human(h)PYY (23–117 pmol), microinjected unilaterally into the DVC resulted in a similar maximal increase in net acid secretion reaching 68±11 and 89±31 μmol 90 min−1respectively.Rat/hNPY and pNPY (47 pmol) microinjected into the DVC induced a similar net gastric acid secretion (27±8 and 23±8 μmol 90 min−1respectively) and a higher dose (116 pmol) tended to reduce the response.Pancreatic polypeptide (PP, 4–46 pmol), [Leu31,Pro34]r/hNPY (47 and 117 pmol) and the Y2 selective agonists, hPYY3‐36, pNPY5‐36and pNPY13‐36(25–168 pmol) microinjected into the DVC failed to influence basal gastric acid secretion.The rank order of potency of PYY[Pro34]r/pPYY=[Pro34]hPYY>r/hNPY=pNPY to stimulate gastric acid secretion upon injection into the DVC and the ineffectiveness of PP, [Leu31,Pro34]NPY and C‐terminal NPY/PYY fragments suggest that a PYY‐preferring receptor subtype may be involved in mediating the stimulating effect.British Journal of Pharmacology(1998)123, 1549–1554; doi:10.1038/sj.bjp.0701767