SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus.
SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus.
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DOI：
10.1038/s42003-021-02220-z
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发表时间：
2021-06-03
影响因子：
5.9
通讯作者：
Qin Z
中科院分区：
文献类型：
--
作者：
Chen J;Dai L;Barrett L;James J;Plaisance-Bonstaff K;Post SR;Qin Z
新型冠状病毒SARS-CoV-2（2019冠状病毒病（COVID-19）的病原体，一种呼吸道疾病）的爆发，自2019年底以来已感染近1亿人，造成200多万人死亡，并造成全球社会和经济混乱。由于SARS-CoV-2感染宿主细胞的机制及其发病机制在很大程度上仍不清楚，目前尚无有效的抗病毒药物。除了严重的呼吸道和全身症状外，几种合并症会增加致死性疾病结局的风险。因此，需要调查COVID-19对患者原有疾病（如癌症和其他传染病）的影响。在目前的研究中，我们报告了SARS-CoV-2编码的蛋白和一些目前使用的抗COVID-19药物能够通过操纵细胞内信号通路诱导卡波西肉瘤相关疱疹病毒（KSHV）的裂解再激活，KSHV是主要的人类致癌病毒之一。我们的数据表明，那些KSHV +患者，特别是在暴露于COVID-19或正在接受治疗的流行地区的患者，即使在他们从COVID-19中完全康复后，也可能增加患病毒相关癌症的风险。Chen等人发现SARS-CoV-2编码的蛋白质和一些抗COVID-19药物可以诱导卡波西肉瘤相关疱疹病毒（KSHV）的裂解再激活，KSHV是人类主要的致癌病毒之一。这项研究表明，暴露于COVID-19或接受其治疗的KSHV阳性患者可能会增加患病毒相关癌症的风险，即使他们已经从COVID-19中完全康复。
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of Coronavirus Disease-2019 (COVID-19), a respiratory disease, has infected almost one hundred million people since the end of 2019, killed over two million, and caused worldwide social and economic disruption. Because the mechanisms of SARS-CoV-2 infection of host cells and its pathogenesis remain largely unclear, there are currently no antiviral drugs with proven efficacy. Besides severe respiratory and systematic symptoms, several comorbidities increase risk of fatal disease outcome. Therefore, it is required to investigate the impacts of COVID-19 on pre-existing diseases of patients, such as cancer and other infectious diseases. In the current study, we report that SARS-CoV-2 encoded proteins and some currently used anti-COVID-19 drugs are able to induce lytic reactivation of Kaposi’s sarcoma-associated herpesvirus (KSHV), one of major human oncogenic viruses, through manipulation of intracellular signaling pathways. Our data indicate that those KSHV + patients especially in endemic areas exposure to COVID-19 or undergoing the treatment may have increased risks to develop virus-associated cancers, even after they have fully recovered from COVID-19. Chen et al. find that SARS-CoV-2 encoded proteins and some anti-COVID-19 drugs can induce lytic reactivation of Kaposi’s sarcoma-associated herpesvirus (KSHV), one of the major human oncogenic viruses. This study suggests that KSHV-positive patients exposed to COVID-19 or undergoing its treatment may have increased risks to develop virus-associated cancers, even after they have fully recovered from COVID-19.
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影响因子：
39.3
作者：
Wang K;Chen W;Zhang Z;Deng Y;Lian JQ;Du P;Wei D;Zhang Y;Sun XX;Gong L;Yang X;He L;Zhang L;Yang Z;Geng JJ;Chen R;Zhang H;Wang B;Zhu YM;Nan G;Jiang JL;Li L;Wu J;Lin P;Huang W;Xie L;Zheng ZH;Zhang K;Miao JL;Cui HY;Huang M;Zhang J;Fu L;Yang XM;Zhao Z;Sun S;Gu H;Wang Z;Wang CF;Lu Y;Liu YY;Wang QY;Bian H;Zhu P;Chen ZN
通讯作者：
Chen ZN
影响因子：
3.7
作者：
Chen, Jungang;Del Valle, Luis;Qin, Zhiqiang
通讯作者：
Qin, Zhiqiang
DOI：
10.2147/phmt.s142816
发表时间：
2018
期刊：
Pediatric health, medicine and therapeutics
影响因子：
--
作者：
El-Mallawany NK;McAtee CL;Campbell LR;Kazembe PN
通讯作者：
Kazembe PN
通过致癌疱疹病毒直接激活Emmprin和相关的发病机理。
影响因子：
11.2
作者：
Qin Z;Dai L;Slomiany MG;Toole BP;Parsons C
通讯作者：
Parsons C
影响因子：
4
作者：
Osawa, Itsuki;Okamoto, Koh;Moriya, Kyoji
通讯作者：
Moriya, Kyoji