Identification of neoplasias of breast tissues using a powder diffractometer.
Identification of neoplasias of breast tissues using a powder diffractometer.
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使用粉末衍射仪鉴定乳腺组织的肿瘤。
DOI：
10.1269/jrr.08027
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发表时间：
2008
影响因子：
2
通讯作者：
C. A. Pelá
中科院分区：
文献类型：
--
作者：
O. R. Oliveira;A. Conceição;D. M. Cunha;M. Poletti;C. A. Pelá
进行了一项调查，以研究人类乳腺样本的散射光子的角分布的潜在用途，用于快速识别乳腺组织的肿瘤。这项技术有可能应用于乳腺癌的诊断辅助。在这项工作中，商业粉末衍射仪被用于获得来自乳腺组织的散射轮廓，组织病理学分类为正常乳腺组织、纤维腺瘤（良性乳腺疾病）和癌（恶性乳腺疾病），在区间0.02A（-1）< x < 0.62A（-1）。详细讨论了实验方法和数据校正，包括背景扣除、偏振、自衰减和几何效应。通过对水样的分析验证了实验方法的有效性。结果表明，散射轮廓是每种组织的独特印象，与它们的微观形态特征相关。多变量分析应用于这些配置文件，以验证这些散射配置文件所携带的信息是否允许正常，良性和恶性乳腺组织之间的区分。统计分析结果表明，完成了75%的分析样品的正确识别。该方法正确鉴别正常与肿瘤的敏感性和特异性分别为95.6%和82.3%，而鉴别良恶性肿瘤的敏感性和特异性分别为78.6%和62.5%。这些初步结果表明，使用商业粉末衍射仪提供高灵敏度的快速诊断是可行的。
An investigation was carried out to study the potential use of the angular distribution of scattered photons by human breast samples for a rapid identification of neoplasias of breast tissues. This technique has possible applications as diagnostic aid for breast cancer. In this work, a commercial powder diffractometer was used to obtain the scattering profiles from breast tissues histopathologically classified as normal breast tissues, fibroadenomas (benign breast diseases) and carcinomas (malignant breast diseases), in the interval 0.02A(-1) < x < 0.62A(-1). The experimental methods and data corrections are discussed in detail, and they included background subtraction, polarization, self-attenuation and geometric effects. The validation of the experimental procedure was achieved through an analysis of water sample. The results showed that the scattering profile is a unique impression of each type of tissue, being correlated with their microscopic morphological features. Multivariate analysis was applied to these profiles in order to verify if the information carried by these scattering profiles allow the differentiation between normal, benign and malignant breast tissues. The statistical analysis results showed that a correct identification of 75% of the analyzed samples is accomplished. The values of sensibility and specificity of this method in correctly differentiating between normal and neoplastic samples were 95.6% and 82.3%, respectively, while the values for differentiation between benign and malignant neoplasias were 78.6% and 62.5%. These initial results indicate the feasible use of commercial powder diffractometer to provide a rapid diagnostic with a high sensitivity.