Tremor varies as a function of the temporal regularity of deep brain stimulation
Tremor varies as a function of the temporal regularity of deep brain stimulation
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DOI：
10.1097/wnr.0b013e3282f9e45e
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发表时间：
2008-03-26
期刊：
影响因子：
1.7
通讯作者：
Grill, Warren M.
中科院分区：
文献类型：
--
作者：
Birdno, Merrill J.;Kuncel, Alexis M.;Grill, Warren M.
刺激频率是决定脑深部刺激(DBS)缓解震颤效果的主要因素之一。然而，DBS的疗效可能不仅取决于刺激的平均频率，还取决于刺激的时间模式。我们在术中测量了时间上不规则的DBS(不恒定的脉搏间期)对震颤的影响。随着不规则高频DBS列车变异系数的增大，其减震效果变差(混合效应回归模型，P
The frequency of stimulation is one of the primary factors determining the effectiveness of deep brain stimulation (DBS) in relieving tremor. DBS efficacy, however, may depend not only on the average frequency of stimulation, but also on the temporal pattern of stimulation. We conducted intraoperative measurements of the effect of temporally irregular DBS (nonconstant interpulse intervals) on tremor. As the coefficient of variation of irregular high frequency DBS trains increased, they became less effective at reducing tremor (mixed effects regression model, P