Shaping Fission Yeast with Microtubules
Shaping Fission Yeast with Microtubules
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DOI：
10.1101/cshperspect.a001347
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发表时间：
2009-07-01
影响因子：
7.2
通讯作者：
Martin, Sophie G.
中科院分区：
文献类型：
--
作者：
Chang, Fred;Martin, Sophie G.
对于细胞的形态发生，细胞必须在细胞表面的特定位置建立不同的空间域。本文综述了分裂酵母裂糖酵母（Schizosaccharomyces pombe）细胞极性的分子机制。这些是简单的杆状细胞，在细胞顶端形成皮层结构域，用于细胞生长，在细胞中间形成细胞分裂。在这两种情况下，基于微管的系统通过打破对称性来帮助塑造细胞，提供内源性空间线索来定位这些位点。动态微管的正端将极性因子传递到细胞尖端，导致GTPase cdc42p和肌动蛋白组装机制的局部激活。微管束通过细胞核和胞质分裂因子mid1p定位分裂面。最近的研究进展表明，细胞极化的时空调节是如何整合许多因素的，包括历史标志、积极和消极控制以及通路之间的竞争。
For cell morphogenesis, the cell must establish distinct spatial domains at specified locations at the cell surface. Here, we review the molecular mechanisms of cell polarity in the fission yeast Schizosaccharomyces pombe. These are simple rod-shaped cells that form cortical domains at cell tips for cell growth and at the cell middle for cytokinesis. In both cases, microtubule-based systems help to shape the cell by breaking symmetry, providing endogenous spatial cues to position these sites. The plus ends of dynamic microtubules deliver polarity factors to the cell tips, leading to local activation of the GTPase cdc42p and the actin assembly machinery. Microtubule bundles contribute to positioning the division plane through the nucleus and the cytokinesis factor mid1p. Recent advances illustrate how the spatial and temporal regulation of cell polarization integrates many elements, including historical landmarks, positive and negative controls, and competition between pathways.