Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring
Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring
复制标题
DOI：
10.1016/j.jaci.2016.02.042
复制
发表时间：
2017-01-01
影响因子：
14.2
通讯作者：
Olsen, Sjurdur F.
中科院分区：
文献类型：
--
作者：
Hansen, Susanne;Strom, Marin;Olsen, Sjurdur F.
背景：母体补充长链n-3多不饱和脂肪酸可通过多种抗炎途径对发育中的胎儿产生免疫效应。目的：在1990年进行的一项为期24年的随机对照试验中，我们的目的是确定孕期补充2.7g长链n-3多不饱和脂肪酸是否可以降低子代哮喘和过敏性呼吸道疾病的风险。方法：随机对照试验包括533名妇女，她们被随机分配到妊娠晚期服用鱼油、橄榄油和不服用鱼油，比例为2：1：1。根据国家强制性处方登记表，与哮喘和过敏性鼻炎治疗相关的处方的完全随访是主要结果。结果：在意向处理分析中，鱼油组与橄榄油组相比，开过哮喘药物的概率显著降低(风险比，0.54，95%CI，0.32~0.90；P=.02)。与橄榄油组相比，鱼油组服用过敏性鼻炎药物的概率也有所降低(风险比，0.70，95%CI，0.47-1.05；P=0.09)，但差异不具有统计学意义。18至19岁时收集的自我报告信息支持这些发现。未发现与18-19岁的肺功能结局或过敏性致敏有关的相关性。结论：母亲补充鱼油可能具有长期预防子代哮喘的潜力。
Background: Maternal supplementation with long-chain n-3 polyunsaturated fatty acids can have immunologic effects on the developing fetus through several anti-inflammatory pathways. However, there is limited knowledge of the long-term programming effects.Objective: In a randomized controlled trial from 1990 with 24 years of follow-up, our aim was to determine whether supplementation with 2.7 g of long-chain n-3 polyunsaturated fatty acids in pregnancy can reduce the risk of asthma in offspring and allergic respiratory disease.Methods: The randomized controlled trial included 533 women who were randomly assigned to receive fish oil during the third trimester of pregnancy, olive oil, or no oil in the ratio 2: 1: 1. The offspring were followed in a mandatory national prescription register, with complete follow-up for prescriptions related to the treatment of asthma and allergic rhinitis as primary outcomes. Furthermore, the offspring were invited to complete a questionnaire (74% participated) and attend a clinical examination (47% participated) at age 18 to 19 years.Results: In intention-to-treat analyses the probability of having had asthma medication prescribed was significantly reduced in the fish oil group compared with the olive oil group (hazard ratio, 0.54, 95% CI, 0.32-0.90; P = .02). The probability of having had allergic rhinitis medication prescribed was also reduced in the fish oil group compared with the olive oil group (hazard ratio, 0.70, 95% CI, 0.47-1.05; P = .09), but the difference was not statistically significant. Self-reported information collected at age 18 to 19 years supported these findings. No associations were detected with respect to lung function outcomes or allergic sensitization at 18 to 19 years of age.Conclusion: Maternal supplementation with fish oil might have prophylactic potential for long-term prevention of asthma in offspring.