Protein C inhibitor, a serpin with functions in- and outside vascular biology
Protein C inhibitor, a serpin with functions in- and outside vascular biology
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DOI：
10.1160/th06-09-0488
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发表时间：
2007-03-01
影响因子：
6.7
通讯作者：
Geiger, Margarethe
中科院分区：
文献类型：
--
作者：
Geiger, Margarethe
人蛋白C抑制剂（PCI）是一种丝氨酸蛋白酶抑制剂，最初被描述为活化蛋白C的抑制剂，具有广泛的蛋白酶反应性。除了其在血液凝固和纤维蛋白溶解级联中的活性外，它似乎还参与了几个生物过程，包括生殖和肿瘤生长。本文综述了PCI的功能、调控和潜在的生物学作用。
Human protein C inhibitor (PCI), a serpin-type protease inhibitor originally described as an inhibitor of activated protein C, has broad protease reactivity. In addition to its activities within the blood clotting and fibrinolytic cascades, it seems to participate in several biological processes including reproduction and tumor growth. This review summarizes the current understanding of PCI function, regulation,and potential biological role.