Easy synthesis of highly fluorescent carbon dots from albumin and their photoluminescent mechanism and biological imaging applications
Easy synthesis of highly fluorescent carbon dots from albumin and their photoluminescent mechanism and biological imaging applications
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白蛋白易合成高荧光碳点及其光致发光机制和生物成像应用
DOI：
10.1016/j.msec.2015.09.066
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发表时间：
2016-01-01
影响因子：
7.9
通讯作者：
Li, Lielie
中科院分区：
文献类型：
--
作者：
Hu, Xiaohua;An, Xueqin;Li, Lielie
以白蛋白为碳源，在室温条件下在水溶液中合成高荧光碳点（CDs）。该CDs具有优异的单色散、优异的光稳定性、不依赖ph的发光、长荧光寿命和高量子产率等特点。利用时间分辨光致发光（PL）衰变的方法探讨了CDs的光致发光机制，结果表明，CDs的光致发光源于缺陷态和本征态的发射。此外，我们对人乳腺癌Bcap-37细胞进行了应用CDs的生物成像，结果表明CDs具有优良的生物相容性、低的细胞毒性和良好的跨膜能力。此外，CDs可以被认为是生物成像中有机染料或半导体量子点（SQDs）的潜在替代品。(C) 2015 Elsevier B.V.版权所有
A simple and green approach was developed to synthesize highly fluorescent carbon dots (CDs) using albumin as a carbon source in aqueous solution at room temperature. The CDs were characterized by excellent monodispersion, superior photostability, pH-independent emission, long fluorescence lifetime and high quantum yield (QY). The photoluminescent (PL) mechanism of CDs was explored by means of time-resolved PL decay, and the results revealed that PL originated from the emission of both defect state and intrinsic state. In addition, biological imaging with the application of CDs was carried out in human breast cancer Bcap-37 cell, which demonstrated that CDs were provided with an excellent biocompatiblity, low cytotoxicity and good transmembrane ability. Besides, CDs could be considered as a potential substitute for organic dyes or semiconductor quantum dots (SQDs) in biological imaging. (C) 2015 Elsevier B.V. All rights reserved.