Novel insights into the cellular basis of atrial fibrillation.
Novel insights into the cellular basis of atrial fibrillation.
复制标题
DOI：
10.1586/erc.10.54
复制
发表时间：
2010-07
影响因子：
2
通讯作者：
Patel VV
中科院分区：
文献类型：
--
作者：
Patel VV
心房颤动是临床上最常见的心律失常。常由肺静脉和心房的异位搏动引起。虽然肺静脉肌细胞最有可能导致心房异位搏动引发房颤，但新出现的证据表明，存在其他细胞群也可能导致房性心律失常。除了窦结样和肠Cajal样细胞，我们最近在小鼠和人类心脏中发现了一种新的黑素细胞样细胞群，可能有助于小鼠心房促炎触发。小鼠心脏黑素细胞样细胞是电兴奋的，并表达肾上腺素能和毒蕈碱受体。缺乏编码多巴色素互变异构酶（Dct）的基因的成年小鼠易患房性心律失常，并且Dct由小鼠和人类心脏黑素细胞表达。虽然Dct表达细胞存在于人类心脏中房性心律失常经常出现的区域，但这些细胞对临床房性心律失常的贡献仍有待确定。
Atrial fibrillation is the most common clinical cardiac arrhythmia. It is often initiated by ectopic beats arising from the pulmonary veins and atria. While pulmonary vein myocytes most likely contribute to atrial ectopic beats initiating atrial fibrillation, emerging evidence suggests the existence of other cell populations that may also contribute to atrial arrhythmias. In addition to sinus node-like and intestinal Cajal-like cells, we recently characterized a novel, melanocyte-like cell population in murine and human hearts that may contribute to atrial arrhythmogenic triggers in mice. Murine cardiac melanocyte-like cells are electrically excitable, and express adrenergic and muscarinic receptors. Adult mice lacking the gene encoding dopachrome tautomerase (Dct) are susceptible to atrial arrhythmias, and Dct is expressed by both murine and human cardiac melanocytes. While Dct-expressing cells are present in human hearts in regions from which atrial arrhythmias often arise, the contribution of these cells to clinical atrial arrhythmias remains to be determined.