Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma.
Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma.
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DOI：
10.1515/mr-2022-0043
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发表时间：
2022-12
期刊：
影响因子：
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通讯作者：
Pajvani, Utpal B
中科院分区：
文献类型：
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作者：
Yu, Junjie;Pajvani, Utpal B
非酒精性脂肪性肝炎（NASH）合并代谢综合征日益成为肝细胞癌（HCC）的主要病因。然而，NASH诱导肝癌的发生机制尚不清楚。从这个角度来看，我们将讨论最近的进展，已经取得了理解肝癌的遗传变化和免疫微环境，以及剩余的问题。基于目前的研究，NASH-HCC可能有新的机制，需要进一步研究。
Non-alcoholic steatohepatitis (NASH) with metabolic syndrome is increasing to be a main cause of hepatocellular carcinoma (HCC). However, the mechanism of tumorigenesis in NASH induced HCC is still not clear. In this perspective, we will discuss the recent progress that has been made to understand the genetic change and the immune microenvironment of HCC, and the remaining questions. Based on the current study, NASH-HCC is likely to have novel mechanism, which needs more investigation in future.