Electrotonic coupling in the inferior olivary nucleus revealed by simultaneous double patch recordings
Electrotonic coupling in the inferior olivary nucleus revealed by simultaneous double patch recordings
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DOI：
10.1152/jn.2002.87.6.3048
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发表时间：
2002-06-01
影响因子：
2.5
通讯作者：
Yarom, Y
中科院分区：
文献类型：
--
作者：
Devor, A;Yarom, Y
下橄榄核（IO）的电紧张性耦合被认为在橄榄神经元产生阈下膜电位振荡和同步进入小脑皮质的攀爬纤维输入中起着至关重要的作用。我们研究了耦合的强度和空间分布的同时双补丁记录从橄榄神经元的脑切片制备。在50%的细胞对中观察到电紧张耦合。的耦合系数（CC），定义为后和prejunctional细胞的电压响应之间的比率，在0.002和0.17之间变化，大多数对弱耦合。在超过75%的对中，CC = 50个神经元形成卷曲和直细胞的两个不同网络。
Electrotonic coupling in the inferior olivary (IO) nucleus is assumed to play a crucial role in generating the subthreshold membrane potential oscillations in olivary neurons and in synchronizing climbing fiber input into the cerebellar cortex. We studied the strength and spatial distribution of the coupling by simultaneous double patch recordings from olivary neurons in the brain slice preparation. Electrotonic coupling was observed in 50% of the cell pairs. The coupling coefficient (CC), defined as the ratio between voltage responses of the post- and the prejunctional cell, varied between 0.002 and 0.17; most of the pairs were weakly coupled. In more than 75% of the pairs, the CC was = 50 neurons forming two distinct networks of curly and straight cells.