Introduction to skin aging
Introduction to skin aging
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DOI：
10.1016/j.jtv.2016.03.002
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发表时间：
2017-02-01
影响因子：
2.5
通讯作者：
Tobin, Desmond J.
中科院分区：
文献类型：
--
作者：
Tobin, Desmond J.
在过去的25年里，皮肤科学已经取得了相当大的发展，部分原因是组学革命，以及对这个器官与身体关键的神经免疫内分泌轴相连的认识。此外，对皮肤病的分层如何允许更有针对性和更有效的治疗有了更多的认识。与此相反的是，人类平均寿命的显着延长，尽管至少在西方，这与生活方式相关的疾病如糖尿病，皮肤癌等的令人担忧的增加是平行的。这些人口趋势带来了更大的紧迫性，以找到许多与年龄相关的外在和内在因素引起的皮肤功能缺陷的临床解决方案。皮肤老化的机制包括活性氧（ROS），线粒体DNA突变和端粒缩短以及激素变化的作用。我们还大大提高了我们对如何利用皮肤相当大的再生能力的理解，通过其显著的干细胞亚群投资。通过这种方式，我们希望开发新的策略来选择性地靶向皮肤进行最佳伤口修复和再生的能力。在这里，皮肤再生能力的无名英雄可能是不起眼的毛囊，充满了上皮细胞，间充质细胞，神经细胞和其他干细胞的恭维。这篇综述介绍了人类皮肤老化的主题，重点是如何维持这个复杂的多细胞型器官的功能是保持老年生活质量的关键。(C)2016年组织活力协会。由爱思唯尔有限公司出版。保留所有权利。
Cutaneous science has seen considerable development In the last 25 years, in part due to the Omics revolution, and the appreciation that this organ is hardwired into the body's key neuro-immuno-endocrine axes. Moreover, there is greater appreciation of how stratification of skin disorders will permit more targeted and more effective treatments. Against this has been how the remarkable extension in the average human life-span, though in the West at least, this parallels worrying increases in lifestyle-associated conditions like diabetes, skin cancer etc. These demographic trends bring greater urgency to finding clinical solutions for numerous age-related deficits in skin function caused by extrinsic and intrinsic factors. Mechanisms for aging skin include the actions of reactive oxygen species (ROS), mtDNA mutations, and telomere shortening, as well as hormonal changes. We have also significantly improved our understanding of how to harness the skin's considerable regenerative capacity e.g., via its remarkable investment of stem cell subpopulations. In this way we hope to develop new strategies to selectively target the skin's capacity to undergo optimal wound repair and regeneration. Here, the unsung hero of the skin regenerative power may be the humble hair follicle, replete with its compliment of epithelial, mesenchymal, neural and other stem cells. This review introduces the topic of human skin aging, with a focus on how maintenance of function in this complex multi-cell type organ is key for retaining quality of life into old age. (C) 2016 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved.