The association of serum trans-nonachlor levels with atherosclerosis.
The association of serum trans-nonachlor levels with atherosclerosis.
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DOI：
10.1080/15287394.2016.1143901
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Crow JA
中科院分区：
文献类型：
--
作者：
Mangum LC;Mangum LH;Chambers JE;Ross MK;Meek EC;Wills RW;Crow JA
最近的流行病学研究表明，接触环境污染物，包括有机氯(OC)杀虫剂或其代谢物，与动脉粥样硬化等病理的发展密切相关，在这些疾病中，氧化应激起着重要的病因作用。全身性氧化应激的生物标志物有可能将暴露于外来毒物而形成的活性氧物种(ROS)的产生与潜在的病理生理状态联系起来。体液中F2-异前列腺素浓度的测量是目前可用于评估体内稳态氧化应激水平的最准确和最敏感的方法。在目前的研究中，尿中F2-异前列烷浓度和血清中持久性OC化合物p，p‘-二氯二苯基二氯乙烯(DDE)、反式二十八氯(工业氯丹混合物的一种成分)和氧氯丹(一种氯丹代谢物)的水平在横断面研究样本中被量化，并确定了这些因素与动脉粥样硬化临床诊断的相关性。在本研究样本中，尿异前列腺素水平与动脉粥样硬化或血清OC化合物浓度无关。然而，动脉粥样硬化的发生被发现与血清中反式九氢叶酸水平有关。DDE和氧氯丹与动脉粥样硬化无关。这一发现支持了目前的证据，即除了其他已知的风险因素外，暴露于环境因素也是动脉粥样硬化的风险因素。
Recent epidemiological studies suggest a strong association between exposure to environmental contaminants, including organochlorine (OC) insecticides or their metabolites, and development of pathologies, such as atherosclerosis, in which oxidative stress plays a significant etiological role. Biomarkers of systemic oxidative stress have the potential to link production of reactive oxygen species (ROS), which are formed as a result of exposure to xenobiotic toxicants, and underlying pathophysiological states. Measurement of F2-isoprostane concentrations in body fluids is the most accurate and sensitive method currently available for assessing in vivo steady-state oxidative stress levels. In the current study, urinary concentrations of F2-isoprostanes and serum levels of persistent OC compounds p,p’-dichlorodiphenyldichloroethene (DDE), trans-nonachlor (a component of the technical chlordane mixture) and oxychlordane (a chlordane metabolite) were quantified in a cross-sectional study sample and the association of these factors with a clinical diagnosis of atherosclerosis determined. Urinary isoprostane levels were not associated with atherosclerosis or serum concentrations of OC compounds in this study sample. However, occurrence of atherosclerosis was found to be associated with serum trans-nonachlor levels. DDE and oxychlordane were not associated with atherosclerosis. This finding supports current evidence that exposure to environmental factors is a risk factor for atherosclerosis in addition to other known risk factors.